Timosaponin AIII 产品活性：Timosaponin AIII 能够抑制乙酰胆碱酯酶 (AChE) 的活性，其 IC50 值为 35.4 μM。 产品来源： https://www.medchemexpress.cn/Timosaponin_AIII.html 研究领域：Neuronal Signaling 作用靶点：Cholinesterase (ChE) 来源：植物 | 百合科 | 知母 结构分类：甾体类 | 结构分类 In Vitro: Timosaponin AIII could inhibit acetylcholinesterase (AChE) activity, with an IC50 of 35.4 μM. Timosaponin AIII is identified as a major selective cytotoxic activity in BN108, and its selective cytotoxic activity involves inhibition of mTOR, induction of ER stress and protective autophagy. In Vivo: Of the tested steroidal saponins, Timosaponin AIII (TA3) most potently improves memory deficits. Timosaponin AIII increases the scopolamine-induced reduction in step-through latency by 17% (10 mg/kg), 28% (20 mg/kg), and 43% (40 mg/kg). During the acquisition trial, no differences in latent time are observed. Timosaponin AIII (20, 40 mg/kg, p.o.) potently inhibits this reduction of acetylcholine in scopolamine-treated mouse brain. The inhibitory effect of Timosaponin AIII is comparable to that of tacrine, which is used as a positive control. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Neuronal Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Glycoside Compound Library | Endoplasmic Reticulum Stress Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | Dimethyl sulfoxide | Donepezil Hydrochloride | TMPyP4 tosylate | α-NETA | Galanthamine | Physostigmine salicylate | Scopoletin | Garcinol | Rivastigmine | (-)-Huperzine A | Protopine | Protriptyline hydrochloride | sn-Glycero-3-phosphocholine | Imperatorin | Acetylcholinesterase, Fly head | Hemicholinium 3 | Tacrine hydrochloride | Demethoxycurcumin | Linarin | Tacrine | Corynoline | Epiberberine chloride | Pyridostigmine bromide | Sinapine | Buntanetap | Isoimperatorin | Corydaline 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。