Ginkgolide B 产品活性：Ginkgolide B (BN-52021) 是一种萜内酯，一种有效的血小板活化因子拮抗剂。Ginkgolide B 通过激活 PXR 保护内皮细胞免受外源性和内生性物质引起的损伤。Ginkgolide B 可透过脑血屏障。Ginkgolide B 具有抗氧化、抗炎、抗肿瘤和抗凋亡活性。Ginkgolide B 对缺血引起的损伤具有显着的神经保护作用。 产品来源： https://www.medchemexpress.cn/Ginkgolide-B.html 研究领域：GPCR/G Protein | Apoptosis 作用靶点：Platelet-activating Factor Receptor (PAFR) | Apoptosis 来源：植物 | 银杏科 | 银杏 结构分类：萜类 | 二萜 | 结构分类 In Vitro: Ginkgolide B (BN-52021; 30-150 μM; 24 h) inhibits the up-regulation of VCAM-1 and E-selectin protein expression induced by TNF-α (10 ng/mL). Ginkgolide B (30-150 μM; 24, 48 h) increases CYP3A4 mRNA and MDR1 expression. Ginkgolide B (30-150 μM; pretreated for 24 h) reduces Staurosporine-induced (500 nM; 6 h) apoptosis compared with the positive controls, which exhibited marked apoptosis compared with negative controls. Ginkgolide B does not affect Doxorubicin (5 μM; 24 h) induced apoptosis. Ginkgolide B regulates PXR activity and does not affect PXR expression. In Vivo: Ginkgolide B (BN-52021; 20 mg/kg; Intraperitoneally; immediately and 6 hours after ischemia, and thereafter once daily; 14 days) decreases the neurological deficit score. 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Natural Product Library | Anti-Cancer Compound Library | CNS-Penetrant Compound Library | Covalent Screening Library | Lipid Compound Library | Anti-Cardiovascular Disease Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Traditional Chinese Medicine Active Compound Library | Neuroprotective Compound Library | Food-Sourced Compound Library | Rare Diseases Drug Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Coagulation and Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。