耗材描述
Valepotriate
产品活性:Valepotriate 可以从蜘蛛香 (Valeriana jatamansi) 中分离出,具有抗癫痫和抗癌活性。
产品来源: https://www.medchemexpress.cn/valepotriate.html
研究领域:Apoptosis
作用靶点:Apoptosis
来源:植物 | 其他科
结构分类:萜类 | 环烯醚萜
In Vivo: Valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABAA, GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABAB.
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