(S)-Indoximod 产品活性：(S)-Indoximod (1-Methyl-L-tryptophan) 是吲哚胺-2,3-双加氧酶 (IDO) 抑制剂 (Ki: 19 μM)。(S)-Indoximod 可用于癌症和神经疾病研究。 产品来源： https://www.medchemexpress.cn/s-indoximod.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Indoleamine 2,3-Dioxygenase (IDO) 来源：植物 | 豆科 | 相思子 结构分类：酮、醛、酸 | 结构分类 In Vitro: (S)-Indoximod (750 μM, 24 h) reduces IDO activity in HEK293 cells transduced with human IDO1 gene. (S)-Indoximod (0.5 mM, 48 h) makes the cells released from IFN-γ (100 ng/mL)-mediated G1 cell cycle arrest, and then promotes the apoptosis of hepatic stellate cells. In Vivo: (S)-Indoximod (5 mg/day, i.p. for 3 weeks) reverses the Bacillus Calmette-Guerin (BCG)-induced neurotoxicity in mice. (S)-Indoximod (200 mg/kg, oral gavage) shows delayed, lasts longer renoprotective effect than D isomer, and increases survival in the IRI rat model. (S)-Indoximod (1-9 mg/kg, i.p.) reverses cognitive, anxiety, and depressive-like behavior in bile duct ligation (BDL) rats. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Necrostatin-1 | 3-TYP | Epacadostat | Indoximod | Linrodostat | Palmatine chloride | Navoximod | IDO-IN-7 | Coptisine chloride | PF-06840003 | IACS-8968 | GNF-PF-3777 | IDO5L | DP00477 | IDO1/TDO-IN-4 | PCC0208009 | IDO-IN-3 | IDO2-IN-1 | LY-3381916 | PROTAC IDO1 Degrader-1 | BMS-978587 | BMT-297376 | Coptisine Sulfate | IDO-IN-1 | IDO-IN-18 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。