Gracillin 产品活性：Gracillin 是一种可以从植物的根里提取出来的甾体皂苷，有抗肿瘤的特性。Gracillin可诱导癌细胞凋亡 (apoptosis) 和自噬 (autophagy)。 产品来源： https://www.medchemexpress.cn/Gracillin.html 研究领域：Apoptosis | Autophagy 作用靶点：Apoptosis | Autophagy 来源：植物 | 其他科 结构分类：甾体类 | 结构分类 In Vitro: Gracillin (0-10 μM, 6-24 h) shows broad-spectrum inhibitory effects on the cancer cell viability. Gracillin (5 μM) disrupts mitochondrial function, specifically, inhibits ATP production, activates AMPK, inhibits oxygen consumption rate (OCR) ​in H460 and A549 cells. Gracillin (0-10 μM, 6 h) induces ROS generation (indicated by H2DCF-DA) ​in H460, H1299, H226B and A549 cells. Gracillin (0-4 μM, 24 h) blocks cell cycle in G1 phase, and induces apoptosis and autophagy in A549 cells. In Vivo: Gracillin (oral gavage, 10 mg/kg for xenografts and 20 mg/kg for PDX) inhibits tumor growth of xenograft tumors inoculating lung (H1299), prostate (DU145), and colorectum (HCT116) cancer cells, as well as patient-derived xenograft colon and lung tumors. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Glycoside Compound Library | Lipid Compound Library | Medicine Food Homology Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Cell Death Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。