Dehydrocorydaline (hydroxyl) 产品活性：Dehydrocorydaline hydroxyl (13-Methylpalmatine) 是一种生物碱。Dehydrocorydaline hydroxyl 调节 Bax，Bcl-2 蛋白表达；激活 caspase-7，caspase-8，并使 PARP 失活。Dehydrocorydaline hydroxyl 能增强 p38 MAPK 活化，具有抗炎、抗癌等功效。Dehydrocorydaline hydroxyl 具有强大的抗疟疾作用，并具低细胞毒性 (细胞生存力> 90％)， P. falciparum 3D7 strain (IC50=38 nM)。 产品来源： https://www.medchemexpress.cn/dehydrocorydaline-hydroxyl.html 研究领域：Apoptosis | Epigenetics | Cell Cycle/DNA Damage | MAPK/ERK Pathway | Anti-infection | Autophagy 作用靶点：Bcl-2 Family | Caspase | PARP | p38 MAPK | Parasite | Autophagy 来源：植物 | 罂粟科 | 延胡索 结构分类：生物碱 | 结构分类 In Vitro: Dehydrocorydaline hydroxyl (0-200 μM) treatment significantly inhibits the growth of MCF-7 cells in a dose-dependent manner. The cell viability is decreased by approximate 40% after 24 h of 200 μM Dehydrocorydaline hydroxyl. Dehydrocorydaline hydroxyl (0-200 μM)dose-dependently increases Bax protein expression and decreases Bcl-2 protein expression. Dehydrocorydaline hydroxyl (0-200 μM)induces activation of caspase-7,-8 and the cleavage of PARP without affecting caspase-9. In Vivo: Dehydrocorydaline hydroxyl manifests a low acute toxicity with an LD50 of about 277.5±19.0 mg/kg body weight in mice following oral administration and 21.1±1.4 mg/kg for intraperitoneal injection. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Immunology/Inflammation Compound Library | MAPK Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Oxygen Sensing Compound Library | Pyroptosis Compound Library | Alkaloids Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Antiparasitic Compound library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Angiogenesis-Related Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Osteogenesis Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Cell Death Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Mitophagy Compound Library | Bioactive Compound Library Max | Chloroquine | Olaparib | Z-VAD-FMK | Puromycin dihydrochloride | Venetoclax | Adezmapimod | Navitoclax | Hygromycin B | SB 202190 | Polyinosinic-polycytidylic acid | Doxycycline hyclate | XAV-939 | Talazoparib | Q-VD-OPh | Niraparib | Belnacasan | Afatinib | Acetaminophen | Anisomycin | Sulforaphane | Z-DEVD-FMK | Metronidazole | S63845 | Emricasan | Tauroursodeoxycholate | Saruparib | ABT-737 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。