Spinosin 产品活性：Spinosyn 是一种口服有效的 C-糖苷类黄酮，具有神经保护作用。Spinosyn 通过激活 Nrf2/HO-1 通路抑制 Aβ1-42 的产生和聚合。 产品来源： https://www.medchemexpress.cn/spinosin.html 研究领域：Neuronal Signaling 作用靶点：Amyloid-β 来源：植物 | 鼠李科 | 酸枣 结构分类：黄酮类 | 黄酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Spinosin (0-400 μM; 24 h) is safe within the range of 0-100 μM for both N2a/WT and N2a/APP695 cells.Spinosin (6.25-25 μM; 24 h) down-regulates the expression level of APP, the precursor protein to produce Aβ in N2a/WT and N2a/APP695; and also increases the level of Nrf2 and HO-1 protein.Spinosin (10 μM; 24 h) inhibits the oligomerization and fibrillation of Aβ1-42 and reduces its toxicity induced by Aβ (20 μM). In Vivo: Spinosin (10, 20 mg/kg; po; single dose) significantly ameliorates Scopolamine (HY-N0296) (1 mg/kg, i.p.)-induced cognitive impairment and memory impairment in mouse behavioral tasks. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Neuronal Signaling Compound Library | NF-κB Signaling Compound Library | Natural Product Library | Glycoside Compound Library | Medicine Food Homology Compound Library | Phenols Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Alzheimer's Disease Compound Library | Neuroprotective Compound Library | Neurodegenerative Disease-related Compound Library | Plant-Sourced Natural Product Library | Anti-Pulmonary Fibrosis Compound Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | DAPT | β-Amyloid (25-35) | Thioflavin T | β-Amyloid (1-42), human TFA | FPS-ZM1 | Rutin | Colivelin TFA | Azeliragon | Santacruzamate A | 20(S)-Ginsenoside Rg3 | Ginsenoside Rg1 | β-Amyloid (1-42), (rat/mouse) | Tolcapone | Methoxy-X04 | Aducanumab | Geniposide | Notoginsenoside R1 | Semagacestat | Ginsenoside Re | Bavachinin | Emrusolmin | Leucomethylene blue mesylate | Glimepiride | Hoechst 34580 tetrahydrochloride | Hematoxylin | Valiltramiprosate | Direct Blue 1 | β-Amyloid (1-40) (TFA) | β-Amyloid (42-1), human 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。