耗材描述
Carnosol
产品活性:Carnosol 是一种有效的核糖体S6激酶 (RSK2) 抑制剂,可用于胃癌相关研究,其 IC50 值约为 5.5 μM。Carnosol 是一种 Nrf2 激活剂,增加 Nrf2 的水平以及能促进血红素氧合酶 1 (HMOX1) 的表达。
产品来源: https://www.medchemexpress.cn/Carnosol.html
研究领域:MAPK/ERK Pathway | NF-κB | Metabolic Enzyme/Protease
作用靶点:Ribosomal S6 Kinase (RSK) | Keap1-Nrf2 | Endogenous Metabolite
来源:植物 | 菊科 | 大花短枝菊 | 植物 | 唇形科
结构分类:萜类 | 二萜 | 酚类 | 多酚类
In Vitro: It is showed that carnosol has no cytotoxic effects on GES1 cells and 10 μM carnosol strongly suppresses RSK2 activity, but has little effect on any other kinase. Carnosol exerts strong dose-dependent inhibitory effects against RSK2 autophosphorylation and phosphorylation of its substrate ATF1.
In Vivo: Results indicate that Carnosol significantly decreaseS the volume and weight of gastric tumors relative to the vehicle-treated group. Additionally, mice tolerate treatment with carnosol without significant loss of body weight similar to the vehicle-treated group. The phosphorylation of CREB, a direct downstream protein of RSK2, Is strongly inhibited in the carnosol-treated group but the expression of total CREB is relatively unchanged.
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