Morusin 产品活性：Morusin是从Morus alba Linn.分离的去乙烯基化黄酮，具有抗肿瘤，抗氧化，抗菌等各种生物活性。Morusin可抑制 NF-κB 和 STAT3 的活性。 产品来源： https://www.medchemexpress.cn/Morusin.html 研究领域：NF-κB | Stem Cell/Wnt | JAK/STAT Signaling | Anti-infection 作用靶点：NF-κB | STAT | Bacterial 来源：植物 | 其他科 结构分类：黄酮类 | 黄酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Morusin exhibits a dose- and time-dependent inhibitory effect on murine and human breast cancer cells. IC50 is 9.48 μg/mL for normal mammary epithelial cells (MCF-10A); 2.03 and 1.87 μg/mL for murine breast cancer cells (4 T1 and EMT6); and 2.71 and 3.86 μg/mL for human breast cancer cells (MCF-7 and MDA-MB-231), respectively, the maximal inhibition of cell growth (>80 %) is obtained at 8 μg/mL. The apoptotic cells in morusin treated breast cancer cells are increased significantly in a dose-dependent manner. Morusin significantly inhibits the growth and clonogenicity of human colorectal cancer HT-29 cells. Morusin also inhibits the phosphorylation of IKK-α, IKK-βand IκB-β, increases expression of IκB-α, and suppresses nuclear translocation of NF-κB and its DNA binding activity. Dephosphorylation of NF-κB upstream regulators PI3K, Akt and PDK1 is also displayed. In addition, activation of caspase-8, change of mitochondrial membrane potential, release of cytochrome c and Smac/DIABLO, and activation of caspase-9 and -3 are observed at the early time point. Downregulation in the expression of Ku70 and XIAP is exhibited afterward. Morusin suppresses viability of prostate cancer cells, but little effect in normal human prostate epithelial cells. Morusin also reduces STAT3 activity by inhibiting its phosphorylation, nuclear accumulation, and DNA binding activity. In addition, morusin down-regulated expression of STAT3 target genes encoding Bcl-xL, Bcl-2, Survivin, c-Myc and Cyclin D1. It induces apoptosis in human prostate cancer cells by reducing STAT3 activity. In Vivo: Morusin retards the growth of breast cancer significantly. Mean tumor weight of the control mice is 1.14±0.30 g, and those of the mice administrated with 5 and 10 mg/kg of morusin are 0.61±0.23 and 0.41±0.10 g, respectively, tumor inhibitory rates are 46.5 %, and 64.1 %, respectively. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Kinase Inhibitor Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Small Molecule Immuno-Oncology Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Antibacterial Compound Library | Medicine Food Homology Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Liver Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Highly Selective Inhibitors Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Rapamycin | Phorbol 12-myristate 13-acetate | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Bortezomib | Etoposide | G-418 disulfate | Nigericin sodium salt | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | BAY 11-7082 | Stattic | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Everolimus | Doxycycline hyclate | Tacrolimus | Methotrexate | Streptozotocin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。