Sanggenon C 产品活性：Sanggenon C 是一种黄酮类化合物，通过抑制钙调神经磷酸酶/NFAT2 途径对心脏肥大和纤维化发挥保护作用。Sanggenon C 通过阻断 ERK 信号通路来抑制线粒体分裂，从而诱导细胞凋亡。Sanggenon C 通过抑制 NF-κB 活性，抑制 RAW264.7 细胞中诱导型一氧化氮合酶的表达，以及 TNF-α 刺激的细胞粘附和 VCAM-1 的表达。Sanggenon C 具有抗氧化、抗炎和抗肿瘤作用。 产品来源： https://www.medchemexpress.cn/sanggenon-c.html 研究领域：Metabolic Enzyme/Protease | Stem Cell/Wnt | MAPK/ERK Pathway | NF-κB | Apoptosis 作用靶点：Phosphatase | ERK | NF-κB | Apoptosis 来源：植物 | 桑科 | 桑 结构分类：黄酮类 | 二氢黄酮醇 | 酚类 | 多酚类 | 结构分类 In Vitro: Sanggenon C (4-12 μM; 24 h) inhibits the proliferation of human gastric cancer (GC) cells and greatly reduces the number of GC cell colonies formed. Sanggenon C (6-10 μM; 24 h) inhibits cell cycle arrest and apoptosis of GC cells. Sanggenon C (6-10 μM; 24 h) markedly downregulates the levels of p-ERK. Sanggenon C (6-10 μM; 24 h) induces mitochondrial dysfunction of GC cells. In Vivo: Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 3 weeks) improves impaired cardiac function following aortic banding (AB). Sanggenon C protects against cardiac hypertrophy. Sanggenon C (10, 20 mg/kg/day; Intraperitoneally; for 21 days) suppresses the tumor burden in the nude mice bearing tumor xenografts derived from AGS. Sanggenon C downregulates levels of p-ERK expression. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Phenols Library | Pyroptosis Compound Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Phosphatase Inhibitor Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Metabolic Enzyme Compound Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | MG-132 | Phorbol 12-myristate 13-acetate | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。