Madecassoside 产品活性：Madecassoside是一个从积雪草中分离出来的五环三萜，具有口服有效性，具有抗炎，抗氧化，抗凋亡和抗自噬的特性。Madecassoside 可以抑制 p38 MAPK 和 NF-kB 活性，表现出抗凋亡的特性；可以刺激 Nrf2 的表达，降低神经毒性。Madecassoside 还可以被用于治疗内分泌疾病，心血管疾病，皮肤病等其它疾病。 产品来源： https://www.medchemexpress.cn/Madecassoside.html 研究领域：Metabolic Enzyme/Protease | Apoptosis | Autophagy | NF-κB | MAPK/ERK Pathway 作用靶点：Endogenous Metabolite | Apoptosis | Autophagy | Keap1-Nrf2 | p38 MAPK | Caspase 来源：植物 | 菊科 | 香万寿菊 | 植物 | 伞形科 结构分类：萜类 | 三萜 | 结构分类 In Vitro: Madecassosid (30, 100 μmol/L, 12 h) increases cell viability of oxidative injuried human umbilical vein endothelial cells (HUVECs). Madecassosid (10-100 μmol/L, 12 h) inhibits phosphorylation of p38 MAPK and activaty of Caspase-3, and therefore exhibits an antiapoptotic activity. Madecassosid (10-100 μg/L) exhibits anxioxidative activity against melanocyte dendtrites retraction, maintaining mitochondrial membrane potential and Ca2+ homeostasis. Madecassosid (10 μM, 24 h) prevents inflammation and autophagy of neuronal cells induced by Aβ25–35 through the class III PI3K/Beclin-1/Bcl-2 pathway. In Vivo: Madecassosid (6, 12, 24 mg/kg, i.v.) resolves neurological deficit and ameliorates neuronal apoptosis after focal cerebral ischemia reperfusion. Madecassosid (6, 12, 24 mg/kg, i.v) inhibits activity of NF-kB and so prevents the brain injury. Madecassosid (120 mg/kg, i.g.) reduces LPS-induced neurotoxicity and enhances heme oxygenase proteins via upregulation of Nrf2 in LPS-stimulated neurotoxicity. Madecassosid (10-40 mg/kg,p.o.) ameliorates oxidative damage and imflammation after bleomycin (BLM) instillation, inhibits TGF-β1 overexpression and collagen synthesis, improves collagen degradation. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Reprogramming Compound Library | Glycoside Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Endocrinology Compound Library | Ferroptosis Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Lung Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Neurodegenerative Disease-related Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Anti-Aging Natural Product Library | Pain-Related Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Anti-Gastric Cancer Compound Library | MG-132 | Rapamycin | 3-Methyladenine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | ML385 | Sorafenib | ATP | Retinoic acid | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。