Astragaloside IV 产品活性：Astragaloside IV 是从黄芪中分到的皂苷类物质，能够抑制 ERK1/2 和 JNK 的激活，在乳腺癌细胞 MDA-MB-231 中，能够下调 (MMP)-2，(MMP)-9 的信号通路。 产品来源： https://www.medchemexpress.cn/Astragaloside-IV.html 研究领域：Metabolic Enzyme/Protease | Stem Cell/Wnt | MAPK/ERK Pathway 作用靶点：MMP | ERK | JNK 来源：植物 | 豆科 | 蒙古黄芪 结构分类：萜类 | 三萜 | 结构分类 In Vitro: Astragaloside IV (10, 20, 40 ng/mL) inhibits NSCLC cell growth, whereas low concentrations of astragaloside IV (1, 2.5, 5 ng/mL) has no obvious cytotoxicity on cell viability. Moreover, combined treatment with astragaloside IV significantly increases chemosensitivity to cisplatin in NSCLC cells. On the molecular level, astragaloside IV co-treatment significantly inhibits the mRNA and protein levels of B7-H3 in the presence of cisplatin. Astragaloside IV inhibits the viability and invasive potential of MDA-MB-231 breast cancer cells, suppresses the activation of the mitogen activated protein kinase (MAPK) family members ERK1/2 and JNK, and downregulates matrix metalloproteases (MMP)-2 and -9. In Vivo: Astragaloside IV (10, 20 mg/kg, p.o.) exhibits a potent ability to prevent cognitive deficits induced by transient cerebral ischemia and reperfusion. Astragaloside IV (10 mg/kg) and Astragaloside IV (20 mg/kg) can significantly decrease the levels of these cytokines compared to the Model group. Astragaloside IV significantly inhibits the level of TLR4 and its downstream proteins, suggesting that both MyD88-dependent and -independent pathways play important roles in the anti-inflammatory effects of Astragaloside IV. Astragaloside IV attenuates NLRP3 and cleaved-caspase-1 expression, and reduces Iba1 protein expression. In the mice model, the high-dose astragaloside IV group has a significant increase in the 48-hour survival rate [60% (9/15) vs 13.3% (2/15), P < 0.05], significant reductions in the serum ALT and AST levels (P < 0.01), and significant reductions in liver histopathological indices and the degree of apoptosis of hepatocytes (P < 0.01), as well as a significant reduction in the content of MDA in liver homogenate (P < 0.01) and a significant increase in the activity of SOD. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | MAPK Compound Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Differentiation Inducing Compound Library | Reprogramming Compound Library | Macrocyclic Compound Library | Glycoside Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Terpenoids Library | Glutamine Metabolism Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Anti-Breast Cancer Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Obesity Compound Library | Angiogenesis-Related Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Anti-Colorectal Cancer Compound Library | Anti-Cancer Natural Product Library | Antidepressant Compound Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Anti-Pulmonary Fibrosis Compound Library | Cancer Stem Cells Compound Library | Pain-Related Compound Library | Protease Inhibitor Library | Membrane Protein-targeted Compound Library | Serine/Threonine Kinase Inhibitor Library | Multi-Target Compound Library | Bioactive Compound Library Max | Anti-Fibrosis Compound Library | SP600125 | PD98059 | Doxycycline hyclate | Yoda 1 | Anisomycin | T-5224 | SCH772984 | TBHQ | Tauroursodeoxycholate | JNK-IN-8 | Ilomastat | Chloramphenicol | Ulixertinib | Honokiol | β-Glycerophosphate disodium salt pentahydrate | Edaravone | Isoginkgetin | Cordycepin | Piperlongumine | Temuterkib | Ravoxertinib | C16-PAF | GI254023X | Marimastat | Guggulsterone | Stigmasterol | Salvianolic acid A | o-Phenanthroline 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。