Salvianolic acid C 产品活性：Salvianolic acid C 是细胞色素 P4502C8 (CYP2C8) 的非竞争性抑制剂和细胞色素 P4502J2 (CYP2J2) 中等强度的混合抑制剂，其对 CYP2C8 和 CYP2J2 的 Ki 值分别为 4.82 μM 和 5.75 μM。 产品来源： https://www.medchemexpress.cn/Salvianolic_acid_C.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Cytochrome P450 来源：植物 | 豆科 | 雨树 | 植物 | 唇形科 结构分类：酚类 | 多酚类 | 酮、醛、酸 | 结构分类 In Vitro: Salvianolic acid C is a noncompetitive CYP2C8 inhibitor and a moderate mixed inhibitor of CYP2J2, with Kis of 4.82, 5.75 μM for CYP2C8 and CYP2J2, respectively. 1 and 5 μM Salvianolic acid C (SalC) could significantly inhibit the NO production induced by LPS. Salvianolic acid C decreases the expression of iNOS significantly. Salvianolic acid C inhibits LPS-induced TNF-α, IL-1β, IL-6 and IL-10 overproduction. Salvianolic acid C inhibits LPS-induced NF κB activation. Salvianolic acid C also increases the expression of Nrf2 and HO-1 in BV2 microglial cells. In Vivo: Salvianolic acid C (20 mg/kg) treatment could significantly decrease the escape latency. In addition, SalC (10 and 20 mg/kg) treatment significantly increase the platform crossing number compared with the LPS model group. Systemic administration of Salvianolic acid C down regulates the brain TNF-α, IL-1β and IL-6 levels compared with the model group. The iNOS and COX-2 levels in rat brain cortex and hippocampus are higher than that in the control group, while Salvianolic acid C treatment significantly down regulates the cortex and hippocampus regions. Salvianolic acid C (5, 10 and 20 mg/kg) treatment dose-dependently increases the p-AMPK, Nrf2, HO-1 and NQO1 levels in rat brain cortex and hippocampus. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Metabolism/Protease Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Mitochondria-Targeted Compound Library | Targeted Diversity Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Mitochondrial Protection Compound Library | Metabolic Enzyme Compound Library | Highly Selective Inhibitors Library | Multi-Target Compound Library | Radioprotector Library | Bioactive Compound Library Max | Verapamil | Apigenin | Fenofibrate | Chlorpromazine hydrochloride | Ketoconazole | Abiraterone | Letrozole | 1-Aminobenzotriazole | Itraconazole | Cepharanthine | Quinidine (15% dihydroquinidine) | Clarithromycin | Atovaquone | Diosmetin | Gemfibrozil 1-O-β-glucuronide | Naringin | Fomepizole | Talarozole | Hypericin | Methoxsalen | HET0016 | Memantine hydrochloride | Anastrozole | (S)-Mephenytoin | Sulfaphenazole | Cobicistat | Gemfibrozil 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。