Echinatin 产品活性：Echinatin 是从中草药甘草中分离得到，查尔酮，具有保肝和抗炎作用。在大鼠中，Echinatin 可以被快速吸收和消除并广泛分布，绝对生物利用度约为 6.81％。 产品来源： https://www.medchemexpress.cn/echinatin.html 研究领域：Apoptosis | Autophagy | Immunology/Inflammation 作用靶点：Apoptosis | Autophagy | NOD-like Receptor (NLR) 来源：植物 | 豆科 | 甘草 结构分类：黄酮类 | 查耳酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Echinatin (0-40 μM, 60 min) inhibits Nigericin induced NLRP3 inflammasome activation by binding to HSP90 and suppressing its ATPase activity in LPS-primed BMDMs. Echinatin (0-40 μM, 1-5 days) induces apoptosis and autophagy, and inhibits cell proliferation, migration, invasion in ESCC (KYSE30 and KYSE270 cells). In Vivo: Echinatin (20 and 40 mg/kg, i.p.) inhibits LPS-induced septic shock in mice by inhibiting NLRP3 inflammasome activation. Echinatin (20-80 mg/kg, i.p.) shows cardioprotective effect, and relieves I/R-Induced Myocardial Injury in rats. Echinatin (20 and 50 mg/kg, p.o.) inhibits tumor growth and inhibits the AKT/mTOR pathway of KYSE270-derived tumor mice xenografts. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | NF-κB Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Antioxidant Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Anti-Cardiovascular Disease Compound Library | Medicine Food Homology Compound Library | Phenols Library | Pyroptosis Compound Library | Orally Active Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Cancer Natural Product Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Autoimmune Disease Compound Library | Cell Death Library | Radioprotector Library | Bioactive Compound Library Max | MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | MCC950 sodium | Ruxolitinib | Monomethyl auristatin E 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。