Direct Blue 1 产品活性：Direct Blue 1 (Chicago Sky Blue 6B) 是免疫荧光组织化学中背景自体荧光的一种复染料。Direct Blue 1是一种有效且具有竞争性的 VGLUT 抑制剂。Direct Blue 1 能够抑制 Aβ 结合的小分子 PrP 配体。Direct Blue 1 具有抗炎活性。 产品来源： https://www.medchemexpress.cn/direct-blue-1.html 研究领域：Neuronal Signaling | NF-κB 作用靶点：Amyloid-β | NF-κB In Vitro: Direct Blue 1 (0.1, 1, 10 μM, 9 days) can bind α-synuclein and inhibit its aggregation, thus blocking the proliferation of α-synuclein between SH-SY5Y cells. Direct Blue 1 (5, 10, 20 μM, 48 h) inhibits RANKL-induced osteoclasts and bone resorption in vitro by inhibiting NF-κB signaling and promoting proteasome-mediated MIF degradation. In Vivo: Direct Blue 1 (2 or 8 mg/kg, subcutaneously, for 4 weeks) alleviates inflammatory bone destruction and osteoporosis induced by titanium particles in mice. Direct Blue 1 (7.5 μg, intraventricular injection) alleviates methamphetamine-induced hyperactivity and behavioral sensitization in mice. 相关产品：Phorbol 12-myristate 13-acetate | Bortezomib | DAPT | BAY 11-7082 | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Triptolide | Aspirin | β-Amyloid (25-35) | Pyrrolidinedithiocarbamate ammonium | Thioflavin T | Baicalin | Dihydroartemisinin | β-Amyloid (1-42), human TFA | FPS-ZM1 | 5-Aminosalicylic Acid | Rutin | Parthenolide | CBL0137 hydrochloride | Isoginkgetin | Colivelin TFA | BAY 11-7085 | Rocaglamide | Betulinic acid | SC75741 | Astaxanthin | Azeliragon | Ergothioneine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。