Taurodeoxycholic acid 产品活性：Taurodeoxycholic acid 是一种胆汁酸，可稳定线粒体膜，减少自由基形成。Taurodeoxycholic acid 通过阻断钙介导的凋亡通路以及 Caspase-12 激活来抑制凋亡 (apoptosis)。Taurodeoxycholic acid 对 3-硝基丙酸诱导或稳定遗传的亨廷顿舞蹈病 (HD) 小鼠模型具有神经保护作用。 产品来源： https://www.medchemexpress.cn/Taurodeoxychloic_Acid.html 研究领域：Metabolic Enzyme/Protease | Apoptosis 作用靶点：Endogenous Metabolite | Apoptosis 结构分类：酮、醛、酸 | 结构分类 In Vitro: Taurodeoxycholic acid (50 μM, 100 μM; 4 h) increases oligonucleosomal DNA cleavage and apoptotic nuclei in primary human hepatocytes. Taurodeoxycholic acid (400 μM; 18-24 h) increases DNA fragmentation and PARP cleavage in human liver-derived cell line Huh7 cells, thus induces apoptosis. In Vivo: Taurodeoxycholic acid (50 mg/kg; i.p.; once daliy for 34 d) prevents neuropathology and associated behavioral deficits in the 3-nitropropionic acid rat model of Huntington's disease (HD). Taurodeoxycholic acid (500 mg/kg; s.c.; once every 3 d for 7 weeks) leads to a significant reduction in striatal neuropathology of the R6/2 transgenic HD mouse. 相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | Apoptosis Compound Library | Metabolism/Protease Compound Library | Natural Product Library | FDA-Approved Drug Library | Drug Repurposing Compound Library | Lipid Compound Library | Traditional Chinese Medicine Active Compound Library | FDA Approved & Pharmacopeial Drug Library | Neuroprotective Compound Library | Gut Microbial Metabolite Library | Microbial Metabolite Library | Neurodegenerative Disease-related Compound Library | Food-Sourced Compound Library | Human Metabolite Library | Off-patent Drug Library | Highly Selective Inhibitors Library | Cell Death Library | FDA-Approved Traditional Chinese Medicine Active Compound Library | Bioactive Compound Library Max | MG-132 | Rapamycin | 3-Methyladenine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | ATP | Retinoic acid | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。