耗材描述
4-Quinolinol
产品活性:4-Quinolone (Kynurine) 是喹啉衍生物。Kynurine 通路调节色氨酸代谢,参与神经保护作用。Kynurine 通过抑制抗肿瘤免疫促进肿瘤细胞存活和运动。
产品来源: https://www.medchemexpress.cn/4-quinolinol.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Endogenous Metabolite
结构分类:生物碱 | 喹啉类生物碱 | 结构分类
In Vitro: 4-Quinolone (Kynurine) promotes tumor cell survival and motility by suppressing antitumor immune responses through AhR in an autocrine/paracrine fashion. This system is particularly active in human brain tumors where the activation of AhR enhances the expression of TDO producing more kynurine and kynurinic acid. In the healthy human brain, very low levels of TDO exist, whereas, in human brain tumors, the TDO protein levels increase with malignancy.
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