耗材描述
Relamorelin
产品活性:Relamorelin (RM-131),一种生长素类似物,是一种选择性的生长素释放肽/生长激素促分泌素受体 (GHSR) 激动剂,对 GHS-1a 受体的 Ki 值为 0.42 nM。Relamorelin 是一种五肽,具有中枢渗透性。Relamorelin 增加生长激素水平,加速胃排空,具有用于恶病质、胃轻瘫和胃/肠运动障碍研究的潜力。
产品来源: https://www.medchemexpress.cn/relamorelin.html
研究领域:GPCR/G Protein
作用靶点:GHSR
In Vitro: Relamorelin (RM-131) shows ∼3 times greater affinity for GHS-1a (Ki=0.42 nM) than native ghrelin (Ki=1.12 nM). Relamorelin is 6 times more potent (EC50=0.71 nM) in activating the GHS-1a receptor than native ghrelin (EC50=4.2 nM) as assessed in vitro by calcium mobilization.
In Vivo: Relamorelin (RM-131; 50-500 nmol/kg/day; s.c.; continuous infusion for 5 days) decreases the loss of body mass and fat mass. Relamorelin (500 nmol/kg/day; continuous infusion for 5 days) increases the food intake and weight gain in rats.
RM-131 (250-500 nmol/kg; a single s.c.) stimulates acute food intake in wt but not growth hormone secretagogue receptor (GHR) ko mice.
相关产品:Anamorelin | TC-G-1008 | Ibutamoren Mesylate | PF-5190457 | TM-N1324 | JMV 2959 | des-Gln14-Ghrelin | YIL781 hydrochloride | Capromorelin Tartrate | Relamorelin TFA | L-692429 | AZP-531 | Human growth hormone-releasing factor TFA | L-692585 | (αR,8aS)-GSK1614343 | AZ-GHS-22 | BMS-604992 | BPP-2 | des-Gln14-Ghrelin TFA | Emoghrelin | Ghrelin receptor full agonist-2 | GHRF, bovine | GHRF, porcine
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