耗材描述
Aeroplysinin 1
产品活性:Aeroplysinin 1 ((+)-Aeroplysinin-1),从海洋海绵中分离出的次生代谢产物,对革兰氏阳性细菌 (bacteria) 显示出有效的抗生素作用,并具有针对 HIV-1 的抗病毒活性 (IC50=14.6 μM)。Aeroplysinin 1 具有抗炎,抗血管生成和抗肿瘤活性。Aeroplysinin 1诱导内皮细胞凋亡 (apoptosis)。
产品来源: https://www.medchemexpress.cn/aeroplysinin-1.html
研究领域:Anti-infection | Apoptosis
作用靶点:Bacterial | HIV | Apoptosis
结构分类:抗生素 | 疾病研究 | 抗菌 | 抗生素 | 疾病研究 | 抗癌 | 抗生素 | 疾病研究 | 抗炎/免疫调剂 | 抗生素 | 疾病研究 | 抗病毒 | 抗生素 | 其他类 | 结构分类
In Vitro: Aeroplysinin 1 shows anti-proliferative effect against tumor cells (HT-1080, HTC-116, HeLa, THP-1, NOMO-1 and HL-60 cells), with IC50s ranging from 2.3 to 17 μM.
Aeroplysinin-1 also exhibits an antiviral activity toward HIV-1 caused by inhibition of its reverse transcriptase activity.
Aeroplysinin 1 inhibits P. phosphoreum, C. wailesii, P. minimum and HIV with IC50s of 3.5, 5.6, 7.0 and 14.6 μM.
Aeroplysinin 1 inhibits human endothelial cells (EVLC-2, HMEC, RF-24, and HUVEC cells), with IC50s ranging from 2.6 to 4.7 μM.
(+)-Aeroplysinin-1 (0.25-0.5 μM) blocks the EGF-dependent proliferation of both MCF-7 and ZR-75-1 human breast cancer cells and inhibits the ligand-induced endocytosis of the EGF receptor in vitro.
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