耗材描述
Photo-lysine hydrochloride
产品活性:Photo-lysine hydrochloride,一种新的基于赖氨酸光反应性的氨基酸,它捕获结合赖氨酸翻译后修饰的蛋白质。
产品来源: https://www.medchemexpress.cn/Photo-lysine_hydrochloride_.html
研究领域:Others
作用靶点:Biochemical Assay Reagents
In Vitro: Photo-lysine is designed and synthesized by incorporating a photo-cross-linker (diazirine) into the side chain of natural lysine. Photo-lysine, which is readily incorporated into proteins by native mammalian translation machinery, can be used to capture and identify proteins that recognize lysine post-translational modifications (PTMs), including ‘readers’ and ‘erasers’ of histone modifications. Photo-lysine can be incorporated into MDH2 and mediate photo-cross-linking to fix protein-protein interactions in cells. UV irradiation of cells in the presence of photo-lysine induced robust cross-linking of HSP90β and HSP60. Photo-lysine has higher efficiency than photo-leucine for photo-cross-linking of the two chaperone proteins. Photo-lysine enables capture of the heterodimer of proteins Ku70 and Ku80 within a protein complex. Photo-lysine enables identification of histone- and chromatin-binding proteins.
相关产品:PEG300 | Tween 80 | Corn oil | SBE-β-CD | Hexadimethrine bromide | Solutol HS-15 | Methyl-β-cyclodextrin | HP-β-CD | Cremophor EL | Sodium carboxymethyl cellulose (Viscosity:800-1200 mPa.s) | DL-dithiothreitol | IPTG | Phosal 50 PG | PLGA (50:50) | EGTA | Ac4ManNAz (80% α isomer) | Methyl cellulose | Bovine Serum Albumin | DTNB | FITC-Dextran (MW 70000) | LysoTracker Red | Biotin-azide | 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride | Trifluoromethanesulfonic acid silver | Ethylenediaminetetraacetic acid | NAI-N3 | Gelucire 44/14 | HEPES | Formamide
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