Rocaglamide 产品活性：Rocaglamide (Roc-A) 是从楝科植物中分离出来，可用于咳嗽，受伤，哮喘和炎症性皮肤病。Rocaglamide 是 T 细胞中一种有效的 NF-κB 活化抑制剂。Rocaglamide 是一种有效的选择性热休克因子 1 (HSF1) 活化抑制剂，IC50 约为 50 nM。Rocaglamide 还抑制翻译起始因子 eIF4A 的功能。Rocaglamide 还具有抗癌特性。 产品来源： https://www.medchemexpress.cn/Rocaglamide.html 研究领域：NF-κB | Metabolic Enzyme/Protease | Cell Cycle/DNA Damage 作用靶点：NF-κB | HSP | Eukaryotic Initiation Factor (eIF) 来源：植物 | 楝科 | 椭圆叶米仔兰 结构分类：生物碱 | 其他类生物碱 | 结构分类 In Vitro: Rocaglamide enhances TRAIL-induced apoptosis in resistant HCC cells. Treatment with Rocaglamide alone leads to apoptosis in 9% HepG2 and 11% Huh-7 cells and treatment with TRAIL induces apoptosis in 16% HepG2 and 17% Huh-7 cells. However, the combination of Rocaglamide and TRAIL induces apoptosis in 55% HepG2 and 57% Huh-7 cells, which is evidently more than an additive effect. A similar result is obtained by measurement of cell viability using crystal violet staining. Rocaglamide has the potential to sensitize highly chemoresistant HepG2 and Huh-7 cells to TRAIL-based therapy. In Vivo: Tumor volumes in the Rocaglamide-treated group are 45±12% compared with the control group. Rocaglamide significantly suppresses tumor growth compared with that in the control group. Treatment with Rocaglamide does not lead to any reduction in body weight and no apparent signs of toxicity are observed in the mice during the treatment, suggesting that Rocaglamide is generally tolerated well. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Phorbol 12-myristate 13-acetate | Tamoxifen | Bortezomib | BAY 11-7082 | Palmitic acid | Polyinosinic-polycytidylic acid | TAK-243 | JSH-23 | Shikonin | Sulfasalazine | Tanespimycin | Triptolide | Aspirin | Pyrrolidinedithiocarbamate ammonium | Baicalin | Dihydroartemisinin | VER-155008 | GCN2iB | Geldanamycin | 5-Aminosalicylic Acid | Parthenolide | Ganetespib | CBL0137 hydrochloride | Isoginkgetin | BAY 11-7085 | Luminespib | HA15 | GCN2-IN-1 | Betulinic acid 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。