3-Methyladenine 产品活性：3-Methyladenine (3-MA) 是 PI3K 的抑制剂。它通过抑制class III PI3K广泛作为自噬 (autophagy) 的抑制剂使用。 产品来源： https://www.medchemexpress.cn/3-Methyladenine.html 研究领域：PI3K/Akt/mTOR | Autophagy | Metabolic Enzyme/Protease 作用靶点：PI3K | Autophagy | Mitophagy | Endogenous Metabolite 结构分类：其他类 | 结构分类 In Vitro: 3-Methyladenine (0-10 mM; 0-48 hours) induces caspase-dependent cell death in HeLa cells in a time-and dose-dependent manner. 3-Methyladenine (5 mM; 24 hours) suppresses autophagy in HeLa cells under both glucose-free conditions and normal conditions. 3-Methyladenine (5 mM; 0-48 hours) suppresses conversion of LC3-I to LC3-II (autophagy markers) between 12hours and 48 hours, confirms the inhibitory effects on autophagy. 3-Methyladenine induces cell death is independent of autophagy inhibition. 3-Methyladenine significantly shortens the duration of nocodazole-induced-prometaphase arrest.Note:The recommended concentration of 3-MA is approximately 0.5-10 mM in cell culture. DMSO stock solution is not recommended. We suggest that you can weigh out the amount of 3-MA you required before your experiment. Then please dissolve it in medium and sterilize with a 0.22 μm filter. In Vivo: 3-Methyladenine (1.5 mg/100 g; intraperitoneal injection; 3-24 hours) treatment alleviates sodium taurocholate-induced severe acute pancreatitis (SAP) in rats at both 12 hours and 24 hours. 3-Methyladenine inhibits autophagy of pancreatic acinar cells in sodium taurocholate-tnduced SAP. 3-Methyladenine also shows inhibitory effects on PI3K/Akt signaling pathway and NF-κB signaling pathway in sodium taurocholate-induced SAP. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Rapamycin | Doxorubicin hydrochloride | Olaparib | LY294002 | Dexamethasone | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Mdivi-1 | Etoposide | Adezmapimod | Hydrocortisone | Ruxolitinib | Brefeldin A | Metformin | Estradiol | Quercetin | Nicotinamide | Alpelisib | Prostaglandin E2 | AICAR | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Resveratrol | Cytarabine | Curcumin | 740 Y-P 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。