Rottlerin 产品活性：Rottlerin 是可从 Mallotus Philippinensis 中分到的一种天然产物， 是 PKC 的一个特异性抑制剂，其对 PKCδ 的 IC50 值为 3-6 μM， PKCα，β，γ 的为 30-42 μM，PKCε，η，ζ 为 80-100 μM。Rottlerin 可作为线粒体直接解偶联剂，通过靶向mTORC1 上游的信号级联刺激自噬。Rottlerin 通过活化 caspase 3 诱导细胞凋亡。Rottlerin 抑制 HIV-1 整合和狂犬病病毒 (RABV) 感染。 产品来源： https://www.medchemexpress.cn/Rottlerin.html 研究领域：Epigenetics | TGF-beta/Smad | Autophagy | Apoptosis | Anti-infection 作用靶点：PKC | Autophagy | Apoptosis | HIV | RABV 来源：植物 | 大戟科 | 粗糠柴 结构分类：黄酮类 | 查耳酮 | 酚类 | 多酚类 | 结构分类 In Vitro: Rottlerin (20 μM, 2/6/24 hours) dramatically decreases the cyclin D-1 mRNA levels in a time-dependent manner in primary HMVEC.? Rottlerin (20 μM) exhibits cell proliferation in HMVEC. In Vivo: Rottlerin (20 mg/kg, gavage 5 days per week, once daily, for 6 weeks) inhibits AsPC-1 pancreatic tumor growth in Balb C nude mice with no toxicity.? Rottlerin inhibits tumor cell proliferation, and induces apoptosis through activation of caspase-3 and cleavage of poly(ADP-ribose) polymerase (PARP). 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Apoptosis Compound Library | Epigenetics Compound Library | Kinase Inhibitor Library | TGF-beta/Smad Compound Library | Natural Product Library | Anti-Cancer Compound Library | Antiviral Compound Library | Autophagy Compound Library | Reprogramming Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Medicine Food Homology Compound Library | Phenols Library | Cytoskeleton Compound Library | Traditional Chinese Medicine Active Compound Library | Flavonoids Library | Anti-Cancer Natural Product Library | Antiviral Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Cancer Stem Cells Compound Library | Coagulation and Anti-coagulation Compound Library | Membrane Protein-targeted Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Multi-Target Compound Library | Bioactive Compound Library Max | MG-132 | Phorbol 12-myristate 13-acetate | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Forskolin | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。