Lactimidomycin 产品活性：Lactimidomycin 是从链霉菌中分离出的含戊二酰亚胺的化合物。Lactimidomycin 是一种有效的真核翻译延伸抑制剂，对肿瘤细胞系具有有效的抗增殖作用，并选择性抑制蛋白质翻译。Lactimidomycin 抑制蛋白质合成，IC50 值为 37.82 nM。Lactimidomycin 还是登革热病毒 2 和其他 RNA 病毒的有效且无毒的抑制剂。抗癌和抗病毒活性。 产品来源： https://www.medchemexpress.cn/lactimidomycin.html 研究领域：Anti-infection 作用靶点：Flavivirus | Dengue virus 结构分类：酮、醛、酸 | 结构分类 In Vitro: Lactimidomycin (0.01-100 nM; 24 hours; Hs 579T, HCC 1937, HCC 1395, HCC 2218, BT 474, MCF 7, MDA MB231 cells and MCF 10A) treatment inhibits cell growth with IC50 concentrations in the low nanomolar range, but higher doses are necessary to inhibit growth of the non-tumorigenic breast cell line MCF10A. Lactimidomycin induces a clear dose-responsive inhibition of DENV2 infectious particle production with an EC90 value of 0.4 μM. No measurable decrease in cell viability was detected at concentrations up to 12.5 µM. Lactimidomycin is a potent inhibitor of DENV2 and Lactimidomycin's inhibition of DENV2 translation leads to reduced production of newly infectious particles. Lactimidomycin may protect cells from viral cytopathic effects including apoptosis, likely through inhibition of virus protein production and replication. In Vivo: Lactimidomycin (0.6 mg/kg; intraperitoneal injection; daily; for one month; female nude mice) treatment has an appreciable effect on tumor growth in nude mice. 相关产品：Emricasan | U18666A | Ivermectin | Mycophenolic acid | ML-SA1 | Nafamostat mesylate | Quinine | FR 180204 | Loratadine | Lanatoside C | NITD008 | Naringenin | (+)-JNJ-A07 | ZCL278 | Merimepodib | QL47 | Mosnodenvir | Tiratricol | Nanchangmycin | Cephaeline | KIN1408 | Merbromin | HeE1-2Tyr | SN 2 | T-1105 | NITD-688 | ABMA | Cyclofenil 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。