Carbetocin 产品活性：Carbetocin 是一种催产素 (OT) 类似物，是催产素受体 (oxytocin receptor) 激动剂，Ki 是 7.1 nM。Carbetocin 对催产素受体的嵌合 N 末端 (E1) 具有高亲和力 (Ki=1.17 μM)。Carbetocin 具有用于产后出血研究的潜力。Carbetocin 能透过血脑屏障，可以通过激活 CNS 中的催产素受体而具有类抗抑郁活性。 产品来源： https://www.medchemexpress.cn/Carbetocin.html 研究领域：GPCR/G Protein 作用靶点：Oxytocin Receptor In Vitro: Carbetocin is an agonist with about 10-fold lower affinity for the oxytocin receptor but with significantly higher stability and a longer duration of action. Carbetocin has higher affinity to the chimeric E1 receptor and especially to each of the combinations of E1 with the other extracellular domains, i.e. chimeric receptors E13 (Ki=13 nM), E123 (Ki=56 nM), and E1234 (Ki=37 nM). In Vivo: Carbetocin (2-20 mg/kg; i.p.) has a significant effect of treatment on the percent time spent climbing, swimming and immobile. Carbetocin (1, 10,100 μg/rat, i.c.v.) reveals a dose-dependent increase in the percent time spent swimming and a corresponding reduction in immobility following acute administration of 100 μg/rat. 相关产品：Drug Repurposing Compound Library Plus | FDA-Approved Drug Library Plus | FDA-Approved Drug Library Mini | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | FDA-Approved Drug Library | CNS-Penetrant Compound Library | Drug Repurposing Compound Library | Macrocyclic Compound Library | Endocrinology Compound Library | Anti-COVID-19 Compound Library | NMPA-Approved Drug Library | FDA Approved & Pharmacopeial Drug Library | Rare Diseases Drug Library | Peptide Library | Antidepressant Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Off-patent Drug Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Bioactive Compound Library Max | Oxytocin acetate | L-368,899 hydrochloride | Atosiban acetate | LIT-001 | L-371,257 | (Thr4,Gly7)-Oxytocin | Retosiban | Carbetocin acetate | Cligosiban | [Asp5]-Oxytocin | OT-R antagonist 2 | SHR1653 | TC OT 39 | Vasopressin Dimer (parallel) (TFA) | (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin | (d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin | (d(CH2)51,Tyr(Me)2,Thr4,Orn8,Tyr-NH29)-Vasotocin | (Val3,Pro8)-Oxytocin | Barusiban | Cargutocin | Demoxytocin | Kalata B7 | L-366682 | L-372662 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。