耗材描述
Folinic acid disodium
产品活性:Folinic acid (Leucovorin) disodium 是一种生物叶酸,是维生素 B9 的一种形式。Folinic acid disodium 通常与 Methotrexate (MTX) (HY-14519) 作为救援剂一起给药,以降低 MTX 诱导的毒性。Folinic acid disodium 和氟尿嘧啶辅助化疗对结肠癌有效。
产品来源: https://www.medchemexpress.cn/folinic-acid-disodium.html
研究领域:Metabolic Enzyme/Protease | Cell Cycle/DNA Damage
作用靶点:Endogenous Metabolite | Antifolate
结构分类:其他类 | 结构分类
In Vitro: Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h.
In Vivo: Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice).
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