Brefeldin A 产品活性：Brefeldin A (BFA) 是一种内酯抗生素，是蛋白质运输的特定抑制剂。Brefeldin A 阻断分泌蛋白和膜蛋白从内质网向高尔基体的转运。Brefeldin A 也是一种自噬 (autophagy) 和 mitophagy 抑制剂。Brefeldin A 还是一种 CRISPR/Cas9 激动剂，可抑制 HSV-1病毒，并具有抗癌活性。 产品来源： https://www.medchemexpress.cn/Brefeldin-A.html 研究领域：Autophagy | Cell Cycle/DNA Damage | Anti-infection 作用靶点：Autophagy | CRISPR/Cas9 | Mitophagy | HSV | Antibiotic | Bacterial 结构分类：抗生素 | 疾病研究 | 抗癌 | 抗生素 | 疾病研究 | 抗病毒 | 抗生素 | 大环内脂类 | 结构分类 In Vitro: Brefeldin A (BFA) treatment for 15 h or 40 h, causes dramatic swelling of the Endoplasmic Reticulum (ER) and shifts its localization to the periphery of normal rat kidney (NRK) cells. Prolonged Brefeldin A treatment results in marked disruption of the MT and actin cytoskeleton. ADP-ribosylation of BARS is mediated by formation of a conjugate between Brefeldin A and ADPR. BARS shows BAC binding when incubated with the medium from the BFA-treated CD38+ HeLa cells. Brefeldin A induces anchorage-independent cell death in MDA-MB-231 breast cancer cells, inhibits the formation of MDA-MB-231 colonies in 3D and 2D cultures and inhibits the migration and MMP 9 (Matrix Metallopeptidase 9) activity of MDA-MB-231. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Cell Cycle/DNA Damage Compound Library | Natural Product Library | Anti-Cancer Compound Library | Antiviral Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Macrocyclic Compound Library | Antibacterial Compound Library | Medicine Food Homology Compound Library | Traditional Chinese Medicine Active Compound Library | Antibiotics Library | Anti-Breast Cancer Compound Library | Microbial Metabolite Library | Mitochondria-Targeted Compound Library | Anti-Cancer Natural Product Library | Antiviral Traditional Chinese Medicine Active Compound Library | Cysteine Targeted Covalent Library | Mitochondrial Toxicity Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | Multi-Target Compound Library | Bioactive Compound Library Max | Rapamycin | 3-Methyladenine | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Olaparib | Dexamethasone | 2-Deoxy-D-glucose | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Mdivi-1 | Etoposide | Adezmapimod | G-418 disulfate | Ruxolitinib | Nigericin sodium salt | Cyclosporin A | 5-Azacytidine | CCCP | Metformin | Estradiol | Quercetin | Bleomycin sulfate | AICAR | Ionomycin | Hygromycin B | Mitomycin C 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。