IRL-1620 TFA 产品活性：IRL-1620 (TFA) 是高效，选择性的内啡肽受体 (endothelin receptor) B 型激动剂，Ki 值为 16 pM。 产品来源： https://www.medchemexpress.cn/irl-1620-tfa.html 研究领域：GPCR/G Protein 作用靶点：Endothelin Receptor In Vitro: IRL-1620 (TFA) is the most potent and specific ligand for the ETB receptor (KiETA/ KiETB=120,000) as judged by the Ki values for ETA (19 μM) and ETB (16 PM) receptors. IRL-1620 (TFA) is 60 times more selective for the ETB receptor than ET-3 (KiETA/ KiETB=1,900). In Vivo: IRL-1620 (TFA) (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL-1620.?? ? IRL-1620 (TFA) (1-100 nM) increases cytosolic Ca2+ in the vascular endothelium ([Ca]E) with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone with an increase in [Ca]E, in rat aorta,. ? IRL-1620 (TFA) improves both acquisition (learning) and retention (memory) on the water maze task and enhances angiogenic and neurogenic remodeling. Rats treated with IRL-1620 significantly reduces the cognitive impairment induced by Aβ. IRL-1620 treatment enhances the number of blood vessels labeled with VEGF compared to vehicle treatment. 相关产品：Bioactive Compound Library Plus | Peptide Library | Endothelin 1 (swine, human) | Bosentan | Macitentan | Ambrisentan | BQ-788 | Atrasentan hydrochloride | BQ-123 | Carperitide acetate | Endothelin-3, human, mouse, rabbit, rat TFA | Atrial Natriuretic Peptide (ANP) (1-28), rat | Sulfisoxazole | Sitaxsentan sodium | Sparsentan | Zibotentan | Clazosentan | A-192621 | Aprocitentan | Nebentan potassium | Darusentan | IRL 2500 | Tezosentan | Avosentan | Ro 46-8443 | BMS 182874 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。