(R)-(-)-Gossypol 产品活性：(R)-(-)-Gossypol (AT-101) 是天然产物 Gossypol 的左旋异构体。(R)-(-)-Gossypol (AT-101) 结合到 Bcl-2，Mcl-1 和 Bcl-xL 蛋白，Ki 值分别为 260±30 nM，170±10 nM 和 480±40 nM。 产品来源： https://www.medchemexpress.cn/AT-101.html 研究领域：Apoptosis | Autophagy 作用靶点：Bcl-2 Family | Autophagy 来源：植物 | 锦葵科 | 棉属 结构分类：酚类 | 结构分类 In Vitro: The natural racemic Gossypol has two enantiomers, namely the (R)-(-)-Gossypol (AT-101) and (+)-Gossypol enantiomers. (R)-(-)-Gossypol (AT-101) and (+)-Gossypol binds to Bcl-2 or Bcl-xL with similar binding affinities, AT-101 is more potent than (+)-Gossypol in inhibition of cell growth and induction of apoptosis, possibly due to the influence of serum in the cell culture experiments. The racemic form and each of the enantiomers of Gossypol are tested against UM-SCC-6 and UM-SCC-14A in 6-day MTT assays. AT-101 exhibits greater growth inhibition relative to (±)-Gossypol than (+)-Gossypol in both cell lines tested (P50 of 2-5 μM and a less sensitive group with IC50 clusters around 10 μM. (R)-(-)-Gossypol (AT-101) is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Ki values of 260±30 nM, 170±10 nM, and 480±40 nM, respectively. 相关产品：Natural Product Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Natural Product Library | Anti-Cancer Compound Library | Clinical Compound Library | Autophagy Compound Library | Drug Repurposing Compound Library | Phenols Library | Anti-Blood Cancer Compound Library | Mitochondria-Targeted Compound Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Anti-Prostate Cancer Compound Library | Cell Death Library | Anti-Hematopathy Compound Library | Anti-Ovarian Cancer Compound Library | Multi-Target Compound Library | Mitophagy Compound Library | Bioactive Compound Library Max | Venetoclax | Navitoclax | Polyinosinic-polycytidylic acid | Sulforaphane | S63845 | ABT-737 | A-1331852 | Chlorin e6 | AZD-5991 | BT2 | BAI1 | A-1155463 | MIK665 | Estradiol benzoate | Obatoclax Mesylate | Amantadine | Benzbromarone | Chelerythrine chloride | Dehydrocorydaline | WEHI-539 hydrochloride | BI-3802 | AZD4320 | Digitoxin | Bax inhibitor peptide V5 | Gambogic Acid | Tapotoclax | DT2216 | A-1210477 | Gossypol | Daphnetin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。