Forskolin 产品活性：Forskolin (Coleonol) 是一种有效的腺苷酸环化酶 (adenylate cyclase) 激活剂，对于 I 型腺苷酸环化酶，IC50 为 41 nM，EC50 为 0.5 μM。Forskolin 也是一种细胞内 cAMP 形成的诱导剂。Forskolin 诱导多种细胞类型的分化并激活孕烷 X 受体 (PXR) 和 FXR。Forskolin 对心脏产生正性肌力作用，并具有血小板抗凝集和降压作用。Forskolin 也可诱导细胞自噬 (autophagy)。 产品来源： https://www.medchemexpress.cn/Forskolin.html 研究领域：Stem Cell/Wnt | GPCR/G Protein | Metabolic Enzyme/Protease | Autophagy | TGF-beta/Smad | Epigenetics 作用靶点：Organoid | Adenylate Cyclase | FXR | Autophagy | PKC 来源：植物 | 菊科 | Gochnatia polymorpha (Less) Cabr. | 植物 | 唇形科 结构分类：萜类 | 二萜 | 结构分类 In Vitro: Forskolin (Coleonol) is also a potent exosome biogenesis and/or secretion activator in prostate cancer (PC) cells. Forskolin (Fsk) is a naturally occurring diterpene isolated from Coleus forskholii, directly activates adenylyl cyclase (AC) through its catalytic subunit to increase intracellular levels of cyclic adenosine monophosphate (cAMP). Forskolin (Fsk) affects the proliferation of the human T-cell lines such as Kit 225 and MT-2. Forskolin treatment inhibits the proliferation of both Kit 225 and MT-2 cells in a dose-dependent manner with an IC50 equal to ~5 μM Fsk. Forskolin treatment (10-100 μM) increases cAMPi levels ~5- to 20-fold above basal levels, which reache maximum levels between 50-100 μM Forskolin. In Vivo: The Forskolin (Coleonol)-treated Mrp4-/- mice shows an increased number of Ki67-positive and cleaved caspase 3-positive ECs, a significant decrease in the amount of pericyte coverage, and a reduced number of empty sleeves. In pups exposed to hyperoxia (75% oxygen) from P7 to P12, the Mrp4-/- mice shows a significant increase in the unvascularized retinal area. The average blood glucose in the healthy rat group is 102.12±1.94 mg/dL, 101.25±3.56 for control group and 103±2.08 in forskolin group. The data shows that glucose levels at the end of the study are lower in forskolin group, with a significant difference according to the statistical tests applied (p=0.03). 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Kinase Inhibitor Library | Metabolism/Protease Compound Library | Stem Cell Signaling Compound Library | TGF-beta/Smad Compound Library | Natural Product Library | Anti-Cancer Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Covalent Screening Library | Reprogramming Compound Library | Anti-diabetic Compound Library | Lipid Compound Library | Oxygen Sensing Compound Library | Endocrinology Compound Library | Terpenoids Library | Cytoskeleton Compound Library | Exosomes Compound Library | Targeted Diversity Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Nuclear Receptor Compound Library | Cancer Stem Cells Compound Library | Coagulation and Anti-coagulation Compound Library | Antihypertensive Compound Library | Metabolic Enzyme Compound Library | Membrane Protein-targeted Compound Library | Cysteine Targeted Covalent Library | Cell Death Library | Serine/Threonine Kinase Inhibitor Library | Extracellular Vesicles (EVs) Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Phorbol 12-myristate 13-acetate | Y-27632 | Laduviglusib | Staurosporine | SB-431542 | Dorsomorphin | Retinoic acid | Adezmapimod | A 83-01 | DAPT | 5-Azacytidine | MK-2206 dihydrochloride | Trichostatin A | Nicotinamide | Prostaglandin E2 | Ionomycin | SB 202190 | Wortmannin | Valproic acid | IWR-1 | LDN193189 | Obeticholic acid | Go 6983 | RepSox | Ipatasertib | GW 4064 | Chenodeoxycholic Acid | Mitoxantrone 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。