耗材描述
G0-C14
产品活性:G0-C14 是一种阳离子类脂化合物烷基修饰聚氨基胺 (PAMAM) 树状大分子。G0-C14 可用于制备一系列巨噬细胞靶向纳米颗粒 (NPs)。它可用于活性分子和疫苗递送。
产品来源: https://www.medchemexpress.cn/g0-c14.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Liposome
In Vitro: G0-C14 exhibits strong entrapment of mRNA and pDNA with an encapsulation efficiency of above 95%.
Preparation of NPs:
1.Dissolve PolyHCPT and DSPE-PEG3K in DMF to form a homogenous solution at a concentration of 5 mg/mL.
2.Prepare a mixture of 1 nmol of siRNA (0.1 nmol/µL aqueous solution) and G0-C14 (5 mg/mL in DMF) in different N/P molar ratios. Mixed them with the polyHCPT and DSPE-PEG3K solution.
3.Under vigorous stirring (1000 rpm), add the mixture dropwise to 5 mL of deionized water.
4.Transferr the formed NP dispersion to an ultrafiltration device.
5.Ccentrifug at room temperature (2800 rpm×8 min) to remove the organic solvent and free compounds.
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