BAMEA-O16B 产品活性：BAMEA-O16B 是一种脂质纳米颗粒。BAMEA-O16B 结合了二硫键，可以有效地将 Cas9 mRNA 和 sgRNA 传递到细胞中，同时响应细胞内还原环境释放 RNA 进行基因组编辑。BAMEA-O16B 可用于基因编辑的研究。 产品来源： https://www.medchemexpress.cn/bamea-o16b.html 研究领域：Metabolic Enzyme/Protease 作用靶点：Liposome In Vitro: BAMEA-O16B/Cas9 mRNA/sgHPV18 (HeLa cells) treatment significantly prohibits HeLa growth compared to that of a scramble sgRNA and Cas9 mRNA delivery. BAMEA-O16B shows RNA delivery efficiency. BAMEA-O16B shows mRNA encapsulation efficiency. BAMEA-O16B shows GFP knockout efficiency. BAMEA-O16B mediated Cas9mRNA delivery is able to regulate endogenous gene expression. BAMEA-O16B/RNA treated cells shows a higher endosome escape efficiency than that of BAMEA-O16/RNA treatment. BAMEA-O16B/RFP mRNA (HeLa cells) nanoparticles results in efficient RFP expression. In Vivo: BAMEA-O16B/Cas9 mRNA/sgRNA (I.v.) nanoparticle effectively knocks mouse serum proprotein convertase subtilisin/kexin type 9 (PCSK9) level down to 20% of nontreated mouse. BAMEA-O16B/Cas9 mRNA/sgPCSK9 nanoparticle reduces mouse serum PCSK9 down to 20% of that with DPBS injection or BAMEA-O16B/Cas9 mRNA/scramblesgRNA nanoparticle injections. 相关产品：Bioactive Compound Library Plus | D-Lin-MC3-DMA | ALC-0315 | SM-102 | Cholesterol | DOTAP chloride | ALC-0159 | DMG-PEG 2000 | DSPC | C12-200 | DOPE | DLin-KC2-DMA | DPPC | DSPE-PEG 2000 | Phosphatidylcholines,soya | 1,2-Dioleoyl-sn-glycero-3-phosphocholine | DSPE-PEG2000-Maleimide | 5A2-SC8 | PEG2000-C-DMG | 18:0 mPEG2000 PE sodium | DODAP | DOTMA | DLinDMA | CKK-E12 | Lipid 5 | DLPC | 1,2-Dioleoyl-sn-glycero-3-phospho-L-serine sodium | 1,2-Dioleoyl-sn-glycero-3-phosphate, sodium salt | DSPE-PEG-Amine, MW 2000 ammonium | 306Oi10 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。