Oleandrin 产品活性：Oleandrin (PBI-05204) 抑制 Na+, K+-ATPase 活性，IC50 为 620 nM。 产品来源： https://www.medchemexpress.cn/Oleandrin.html 研究领域：Membrane Transporter/Ion Channel 作用靶点：Na+/K+ ATPase 来源：植物 | 夹竹桃科 | 夹竹桃 结构分类：甾体类 In Vitro: Study of Na,K-ATPase inhibition shows an IC50 (nM) of 620 for Oleandrin. The inhibition of Na,K-ATPase by Oleandrin confirms that it likely exert its toxic effect through inhibition of sodium pump activity. When treated with a series of concentrations of Oleandrin (0.2-25 nM), the undifferentiated CaCO-2 cells are sensitive as evidenced by an IC50 of 8.25 nM. In contrast, a maximum growth inhibition of only 20% is reached in differentiated CaCO-2 cells even though they are treated with Oleandrin concentrations as high as 25 nM. In Vivo: The effect of Oleandrin is investigated on glioma growth in vivo. To this aim, SCID or C57BL/6 mice are transplanted, respectively, with human U87MG (5×104), U251, GBM19 (5×105), or murine (syngeneic) GL261 (7.5×104) cells into the right striatum and, after 10 d, treated daily with intraperitoneal Oleandrin for an additional 7 d. Oleandrin significantly reduces tumor sizes in human and murine glioma cell models in vivo in a dose-dependent way. High concentrations of Oleandrin (3 mg/kg) are fatal in both models, as expected from the known lethal dose for rodents. Doses of Oleandrin below the lethal dose (0.3 mg/kg) significantly increase the survival time from 32.6±1.4 d to 53.8±9.6 d in mice injected with U87MG cells (n=5-11; p<0.01, log-rank test) and from 23.37±1.2 d to 34.38±3.3 d (n=5-11; p<0.01, log rank test) in mice injected with GL261 cells. 相关产品：Covalent Screening Library Plus | Natural Product Library Plus | Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Membrane Transporter/Ion Channel Compound Library | Natural Product Library | Anti-Cancer Compound Library | Clinical Compound Library | Drug Repurposing Compound Library | Covalent Screening Library | Lipid Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Membrane Protein-targeted Compound Library | Bioactive Compound Library Max | Oleic acid | Ouabain Octahydrate | Digoxin | Bufalin | Ginsenoside Rb1 | Digitoxin | Istaroxime hydrochloride | Tolbutamide | Phlorizin | Rostafuroxin | Deslanoside | Strophanthidin | Biacetyl monoxime | Prilocaine | Neriifolin | (+)-SJ733 | Chlorpropamide | Suloctidil | Transdermal Peptide Disulfide TFA | Acevaltrate | Chloroprocaine hydrochloride | Oxonol VI | Bafilomycin C1 | Annonacin | Citreoviridin | Digoxigenin monodigitoxoside | Digoxin-d3 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。