耗材描述
13-Methyltetradecanoic acid
产品活性:13-Methyltetradecanoic acid (13-MTD),一种具有强效抗癌作用的饱和支链脂肪酸。13-Methyltetradecanoic acid 在多种类型的人类癌细胞中诱导细胞凋亡 (apoptosis)。
产品来源: https://www.medchemexpress.cn/13-methyltetradecanoic-acid.html
研究领域:Apoptosis
作用靶点:Apoptosis
来源:植物 | 豆科 | 大豆
结构分类:酮、醛、酸
In Vitro: 13-Methyltetradecanoic acid (13-MTD; 0-140 μg/mL; 12-24 hours) inhibits cell viability and proliferation in human bladder cancer cells by inducing apoptosis.
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-48 hours) treatments results in significant accumulation of cells with sub-G1 DNA content in a time-dependent manner, with the proportion of sub-G1 phase DNA content ranging from 9.25% to 85.3% over 2-48 hours.
13-Methyltetradecanoic acid (13-MTD; 70 μg/mL; 2-24 hours) down-regulates Bcl-2 and up-regulates Bax. This promotes mitochondrial dysfunction, leading to the release of cytochrome c from the mitochondria to the cytoplasm, as well as the proteolytic activation of caspases. 13-Methyltetradecanoic acid down-regulates AKT phosphorylation and activates phosphorylation of p38 and c-Jun N-terminal kinase (JNK).
In Vivo: 13-Methyltetradecanoic acid (13-MTD; 70 mg/kg/day; oral gavage; daily; for 30 days) significantly suppresses tumor growth in a xenograft model.
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