耗材描述
Sterculic acid
产品活性:Sterculic acid 是一种硬脂酰辅酶 A 去饱和酶 1 (SCD1) 抑制剂。Sterculic acid 特异性抑制 delta-9 去饱和酶 (Δ9D) 活性,IC50 值为 0.9 μM。
产品来源: https://www.medchemexpress.cn/sterculic-acid.html
研究领域:Metabolic Enzyme/Protease
作用靶点:Stearoyl-CoA Desaturase (SCD)
来源:植物 | 梧桐科 | 香苹婆
结构分类:酮、醛、酸 | 结构分类
In Vitro: Sterculic acid (SA) is a cyclopropene fatty acid originally found in the seeds of the plant Sterculia foetida with numerous biological activities[2].Sterculic acid is able to reduce adrenomedullin expression (AP, RP, APS, IML, in preparation)[2].Sterculic acid is also able to mediate anti-inflammatory and protective effects[2].Sterculic acid has a potent luteolytic effect in ovines by inhibition in the synthesis of progesterone, which causes luteal regression[2].
In Vivo: Sterculic acid has been proposed as a potential tool for the treatment of metabolic syndrome (MS) since it inhibits the activity of the stearoyl-CoA desaturase-1 (SCD1)
in vivo[3].
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | A939572 | CAY10566 | Icomidocholic acid | MK-8245 | MF-438 | PluriSIn 1 | GSK1940029 | E6446 dihydrochloride | Elemicin | YTX-465 | XEN723 | CVT-11127 | CVT-12012 | SCD1 inhibitor-4 | SSI-4 | SCD1 inhibitor-1 | SCD1 inhibitor-3 | SCD1/5-IN-1 | T-3764518 | Flurtamone | MK-8245 analog | SCD1-IN-1
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