耗材描述
Hesperidin methylchalcone
产品活性:Hesperidinmethylchalcone (Hesperidinmethylchalcone) 是一种口服活性黄酮类化合物,具有镇痛、抗炎和抗氧化特性。Hesperidin methylchalcone 具有血管保护活性。Hesperidin methylchalcone 抑制氧化应激、细胞因子产生和 NF-κB 激活。Hesperidin methylchalcone 可用于痛风疾病的研究。
产品来源: https://www.medchemexpress.cn/hesperidin-methylchalcone.html
研究领域:NF-κB
作用靶点:NF-κB
来源:植物 | 芸香科 | 柑橘属
结构分类:黄酮类 | 查耳酮
In Vivo: Hesperidin methylchalcone (0.03-3 mg/kg, i.p., once time) inhibits the elevation of renal dysfunction markers (urea and creatinine) induced by SDCF in mice in a dose-dependent manner.
Hesperidin methylchalcone (3 mg/kg, i.p., once time) can effectively counteract the oxidative stress induced by SDCF in renal tissue of mice.
Hesperidin methylchalcone (3 mg/kg, i.p., once time) reduces SDCF-induced renal histopathology, swelling and tubular cells cytotoxicity in mice.
Hesperidin methylchalcone (3-30 mg/kg, p.o., once time) reduces in a dose-dependent manner the MSU-induced hyperalgesia, edema, and leukocyte infiltration in mice.
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