Alisporivir 产品活性：Alisporivir (Debio-025) 是亲环蛋白抑制剂，具有高效的抗丙型肝炎病毒 (HCV) 活性的。 产品来源： https://www.medchemexpress.cn/Alisporivir.html 研究领域：Anti-infection 作用靶点：HCV In Vitro: DEB025 binds to CypA, a peptidyl-prolyl cis-trans isomerase which is a crucial cofactor for HCV replication. Alisporivir (Debio-025) represents the prototype of a new class of non-immunosuppressive cyclophilin inhibitors. Alisporivir prevents HCV protein-mediated collapse of the respiration-driven mitochondrial membrane potential. Alisporivir prevents HCV protein-mediated mitochondrial dysfunction outside the context of apoptosis, calcium overload, production of ROS, dysfunction. In cell culture models, low-micromolar doses of alisporivir block SARS-CoV and MERS-CoV replication. Combination treatment with Alisporivir and ICN-1229 increases the anti-MERS-CoV activity in cell culture. Alisporivir pretreatment stimulates antigen presentation by hepatoma target cells, leading to enhancement of antigen-specific CD8+ T cell activation by 40%. Alisporivir induces an increase of MHC-I and beta-2 microglobulin on the surface of several cell lines. In Vivo: Combination treatment with Alisporivir and ICN-1229 does not protect against SARS-CoV infection in a mouse model. 相关产品：Drug Repurposing Compound Library Plus | Clinical Compound Library Plus | Bioactive Compound Library Plus | Macrocyclic Compound Library | Peptide Library | Cyclic Peptide Library | Resiquimod | Honokiol | Ribavirin | Deferiprone | U18666A | Artemisinin | Asunaprevir | AG-1478 | Myriocin | Grazoprevir | EIDD-1931 | Sofosbuvir | NIM811 | Simeprevir | RO8191 | Vesatolimod | BLT-1 | Mizoribine | GS-443902 trisodium | Elbasvir | Ledipasvir | Glecaprevir | Daclatasvir | Cyclo(Phe-Pro) | Azvudine hydrochloride | Paritaprevir | Telaprevir | Boceprevir | Velpatasvir | Mipomersen sodium 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。