耗材描述
Bonannione A
产品活性:Bonannione A (6-Geranylnaringenin; Mimulone) 是一种异戊二烯类黄酮,一种口服有效的蛋白酪氨酸磷酸酶 1B (PTP1B) 抑制剂,IC50 为 14 µM。Bonannione A 触发半胱天冬酶依赖性细胞凋亡。Bonannione A 通过 p53 介导的 AMPK/mTOR 通路诱导自噬。Bonannione A 显示出抗炎、抗自由基和抗癌活性。
产品来源: https://www.medchemexpress.cn/bonannione-a.html
研究领域:Metabolic Enzyme/Protease | Apoptosis | Autophagy
作用靶点:Phosphatase | Apoptosis | Autophagy
来源:植物 | 玄参科 | 毛泡桐
In Vitro: Bonannione A (0-80 µM; 12, 24 hours) significantly inhibits cell proliferation in a dose- and time-dependent way in cancer cell lines.
Bonannione A (0-60 µM; 24 hours) triggers caspase-dependent apoptosis in A549 cells. Bonannione A increases accumulation of cells at the apoptotic sub-G1 phase and the number of cells at G2/M phase.
Bonannione A (60 µM, 24 h) triggers autophagy without impairment of autophagic flux in A549 cells. Bonannione A remarkably reduced p53 levels.
Bonannione A (60 µM, 0-24 h) remarkably decreased the levels of p53 and phospho-mTOR.
In Vivo: Bonannione A (25 mg/kg; gavage; 48 and 24 h prior to DSS and every 24 h on the following days; for 5days) ameliorates the symptoms of colitis and delayed their onset.
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