耗材描述
Yakuchinone A
产品活性:Yakuchinone A 是一种可以从 Alpinia oxyphylla 果实分离得到的天然产物,可以诱导细胞凋亡 (apoptosis),具有抗癌、抗炎活性。
产品来源: https://www.medchemexpress.cn/yakuchinone-a.html
研究领域:Apoptosis
作用靶点:Apoptosis
来源:植物 | 姜科 | 益智
结构分类:酚类 | 单酚类 | 结构分类
In Vitro: Yakuchinone A acts on A375P, B16F1, B16F10, A549, MCF-7 and HT-29 cell lines with the IC50 values of 14.75, 31.73, 21.71, 26.07, 11.50 and 11.96 μM, respectively.
Yakuchinone A (0-64 μM, 16 h) can reduce IL-17 production in a dose-dependent manner and the IC50 value is 11.5 μM in EL4 (a mouse lymphoma cell line) cells.
In Vivo: Yakuchinone A (50 mg/kg, i.p., daily, 14 days) can reduce the symptoms of EAE in mice in autoimmune encephalomyelitis (EAE) mouse model.
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