耗材描述
Nicotinamide riboside malate
产品活性:Nicotinamide riboside malate 是具有口服活性的 NAD+ 的前体,增加 NAD+ 水平并激活 SIRT1 和 SIRT3。Nicotinamide riboside malate 是维生素 B3 (烟酸) 的来源,可以增强氧化代谢并防止高脂肪饮食诱导的代谢异常。Nicotinamide riboside malate 可以减少阿尔茨海默氏病转基因小鼠模型中的认知退化。
产品来源: https://www.medchemexpress.cn/nicotinamide-riboside-malate.html
研究领域:Cell Cycle/DNA Damage | Epigenetics | Metabolic Enzyme/Protease
作用靶点:Sirtuin | Endogenous Metabolite
结构分类:其他类 | 结构分类
In Vitro: Nicotinamide riboside malate (0.5 mM; 24 hours) reduces the acetylation status of Ndufa9 and SOD2.
Nicotinamide riboside malate increases intracellular and mitochondrial NAD+ content in C2C12, Hepa1.6, and HEK293 cells in a concentration-dependent manner at concentrations ranging from 1-1000 μM.
Nicotinamide riboside malate boosts NAD to restore antiviral poly(ADP-ribose) polymerase (PARP) functions to support innate immunity for coronavirus (CoVs), a cause of COVID-19.
In Vivo: Chronic Nicotinamide riboside malate (p.o.; 400 mg/kg/day; for 16 weeks) supplementation increases plasma and intracellular NAD+ content in a tissue-specific manner.
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