Tanshindiol C 产品活性：Tanshindiol C 是一种 S-腺苷甲硫氨酸竞争性 EZH2 (Histone Methyltransferase) 抑制剂，抑制甲基转移酶活性的 IC50 为 0.55 μM。Tanshindiol C 也是巨噬细胞中 Nrf2 和 Sirtuin 1 (Sirt1) 的激活剂。Tanshindiol C 具有抗癌活性，可用于动脉粥样硬化研究。 产品来源： https://www.medchemexpress.cn/tanshindiol-c.html 研究领域：Epigenetics | NF-κB | Cell Cycle/DNA Damage 作用靶点：Histone Methyltransferase | Keap1-Nrf2 | Sirtuin 来源：植物 | 豆科 | 雨树 | 植物 | 唇形科 结构分类：萜类 | 二萜 | 结构分类 In Vitro: Tanshindiol C (1-10 μM; for 24 h) activates Nrf2 and upregulates Prdx1 expression and mRNA levels in macrophages. Tanshindiol C protects macrophages from oxidized low-density lipoprotein (oxLDL) induced foam cell formation via activation of Prdx1/ABCA1 signaling. Tanshindiol C inhibits both wild-type and A667G mutant (Ki value of 176 nM) EZH2 activity with similar potencies. Tanshindiol C inhibits growth of the cell lines such as Pfeiffer, U-2932 and Daudi (lymphoma), PC3 (prostate cancer), T98G and U87MG (glioma), and A549 (lung cancer), with GI50 values of 1.5 μM, 9.5 μM, 10.6 μM, 4 μM, 6 μM, 5.7 μM and 4.2 μM, respectively. Tanshindiol C (1-5 μM; 72 hours) induces accumulation of Pfeiffer cells in sub-G1 phase, which indicates cells in late apoptosis and necrosis. Tanshindiol C (1-3 μM; 72 hours) increases protein levels of the important apoptosis related protein markers, cleaved caspase-3, caspase-7 and poly ADP-ribose polymerase (PRAP) in the cells.Tanshindiol C significantly decreases the levels of H3K27me3 in cells. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | ML385 | Nicotinamide | Resveratrol | Curcumin | 4-Octyl itaconate | Selisistat | GSK126 | Sulforaphane | Luteolin | TBHQ | Pinometostat | Tazemetostat | Nicotinamide riboside chloride | Dimethyl fumarate | 3-TYP | Omaveloxolone | GSK3326595 | Bardoxolone methyl | 3-Deazaneplanocin A hydrochloride | Fisetin | KI696 | GSK343 | Brusatol | GSK3368715 dihydrochloride | BIX-01294 | EPZ015666 | EZM0414 TFA | Ezetimibe | Chaetocin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。