5-OH-HxMF 产品活性：5-OH-HxMF 是一种羟基化的聚甲氧基黄酮，具有抗炎、抗癌、神经营养和神经保护活性。 产品来源： https://www.medchemexpress.cn/5-oh-hxmf.html 研究领域：Apoptosis 作用靶点：Apoptosis 来源：植物 | 芸香科 | 柑橘 结构分类：黄酮类 | 黄酮 | 结构分类 In Vitro: 5-OH-HxMF (5-20 µM; 48 h) effectively induces PC12 neurite outgrowth accompanied with the expression of neuronal differentiation marker protein growth-associated protein-43(GAP-43). 5-OH-HxMF (20 µM; 0-120 min) causes the enhancement of cyclic AMP response element binding protein (CREB) phosphorylation, c-fos gene expression and CRE-mediated transcription. 5-OH-HxMF significantly reduces the production of nitric oxide and prostaglandin E2 and downregulates inducible nitric oxide synthase (iNOS) and COX-2 expression in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. 5-OH-HxMF inhibits the release of pro-inflammatory cytokines, such as tumor necrosis factor-α and IL-1β, and decreases the transcriptional levels. 5-OH-HxMF significantly inhibits the LPS-induced NF-κB translocation from the cytosol to the nucleus, which is associated with the abrogation of inhibitory IκBα degradation and subsequent decreases in nuclear p65 levels. 5-OH-HxMF inhibits cell growth and induces apoptosis in human leukemia cells. In Vivo: 5-OH-HxMF (topically treated; twice a week; for 20 weeks; 1 and 3 μmol in 200 μL acetone) is an effective antitumor agent and its inhibitory effect is through the down-regulation of inflammatory iNOS and COX-2 gene expression in mouse skin. 相关产品：MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。