Jacaric acid 产品活性：Jacaric acid 是一种共轭亚麻酸，可抑制细胞 PC-3 (IC50 为 11.8 μM)，LNCaP (IC50 sub> 为 2.2 μM) 和 DLD-1 增殖，诱导细胞凋亡 (apoptosis) 和坏死 (necrosis)。Jacaric acid 对前列腺癌和腺癌具有抗癌活性。Jacaric Acid 作为免疫增强剂在小鼠腹腔巨噬细胞中表现出免疫调节活性。Jacaric acid 具有口服有效性。 产品来源： https://www.medchemexpress.cn/jacaric-acid.html 研究领域：Apoptosis 作用靶点：Apoptosis 来源：植物 | 忍冬科 | 距药草 结构分类：酮、醛、酸 | 结构分类 In Vitro: Jacaric acid (0-10 μM) dose- and time-dependently induces apoptosis in cells PC-3 and LNCaP, through an intrinsic and an intrinsic and extrinsic pathway, respectively. Jacaric acid (0-10 μM) induces cytotoxicity in DLD-1 cells through intracellular incorporation and induction of apoptosis via lipid peroxidation. Jacaric acid (50-100 μM) activates the macrophage through secretion of cytokines IFN-γ, IL-1β and TNF-α, enhances the endocytic activity in murine peritoneal macrophages and induces the cytostatic activity in MBL-2 cells. In Vivo: Jacaric acid (1 mg/day/mouse, p.o. for 36 days) exhibits antitumor activity in DLD-1 transplanted athymic nude mice, without significant toxicity. 相关产品：MG-132 | Doxorubicin hydrochloride | Bafilomycin A1 | Tamoxifen | Y-27632 | LY294002 | Paclitaxel | Z-VAD-FMK | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | Actinomycin D | SB-431542 | 5-Fluorouracil | Bortezomib | Deferoxamine mesylate | Oxaliplatin | Trametinib | Sorafenib | Temozolomide | Gemcitabine | Decitabine | Mdivi-1 | Rotenone | Etoposide | Elesclomol | Ruxolitinib | Monomethyl auristatin E | DAPT 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。