Ambruticin 产品活性：Ambruticin (W7783) 是一种口服有效的抗真菌抗生素。Ambruticin 是一类抗生素，可以从 Polyangium cellulosum var. fulvum 菌株中分离出来。Ambruticin 是一种环丙基多烯吡喃酸，具有抗真菌活性。 产品来源： https://www.medchemexpress.cn/ambruticin.html 研究领域：Anti-infection 作用靶点：Antibiotic | Fungal 结构分类：抗生素 | 其他类 | 结构分类 In Vitro: Ambruticin is highly active against the yeast and filamentous phases of H. capsulatum and B. dermatitidis; the MIC range was 0.049 to 0.39 μg/mL, and the order of activity appeared similar to amphotericin B (HY-B0221). Ambruticin MIC is 1.56 μg/mL and the Griseofulvin (HY-17583) MIC was 3.12 μg/mL against M.fulvum. In Vivo: The acute LD50 values for the sodium salt of Ambruticin in mice were: intravenous 315 mg/kg, oral > 1000 mg/kg. Ambruticin is rapidly absorbed by the oral route in mice. Ambruticin (75 mg/kg, gavage) produces a peak serum level of 46 μg/mL with a serum half-life of 3.1 h. Ambruticin (40 mg/kg, oral, twice daily for a total of 10 days) shows protective activity in Guinea pigs infected with a severe T. mentagrophytes challenge. Ambruticin shows protective activity in mice acutely infected with a severe C. albicans challenge. 相关产品：Rapamycin | Ferrostatin-1 | Cycloheximide | Chloroquine | Doxorubicin hydrochloride | Bafilomycin A1 | Dexamethasone | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Etoposide | G-418 disulfate | Nigericin sodium salt | Cyclosporin A | 5-Azacytidine | Brefeldin A | Bleomycin sulfate | Ionomycin | Hygromycin B | Mitomycin C | Resveratrol | Tunicamycin | Doxycycline hyclate | Tacrolimus | Oligomycin | Streptozotocin | Neomycin sulfate | Wortmannin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。