耗材描述
Camalexin
产品活性:Camalexin 是一种植物抗毒素,是从 Camelina sativa (十字花科植物)中分离出来的,具有抗菌,抗真菌,抗增殖和抗癌活性。Camalexin 可诱导活性氧 (ROS) 的产生。
产品来源: https://www.medchemexpress.cn/camalexin.html
研究领域:Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease | Anti-infection
作用靶点:Reactive Oxygen Species | Fungal | Bacterial
来源:植物 | 十字花科 | 亚麻荠
结构分类:生物碱 | 吲哚类生物碱 | 结构分类
In Vitro: Camalexin shows antiproliferative activity against a human breast cancer cell line.
For the oomycetes Phytophthora and Pythium Nep1-like proteins (necrosis and ethylene-inducing peptide 1-like proteins) are the initial triggers of Camalexin synthesis and formation of reactive oxygen species (ROS). ROS appear to be of general relevance for Camalexin formation. Chemical induction of ROS, such as by application of acifluorfen, coincided with Camalexin synthesis. In a screen for enhanced susceptibility to Alternaria brassicicola the esa1 mutant is identified, which shows delayed Camalexin induction. Particularly in response to ROS inducing agents reduced Camalexin levels are synthesized. This crucial role for ESA1 is confirmed by the inability of esa1 mutants to synthesize Camalexin in response to Leptosphaeria maculans. An additional mutant that exhibits greatly reduced Camalexin accumulation is ups1, which is isolated on the basis of diminished expression of a tryptophan biosynthetic enzyme.
相关产品:Natural Product Library Plus | Bioactive Compound Library Plus | Anti-Infection Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Anti-Cancer Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Oxygen Sensing Compound Library | Antifungal Compound Library | Antibacterial Compound Library | Ferroptosis Compound Library | Pyroptosis Compound Library | Alkaloids Library | Anti-Breast Cancer Compound Library | Gut Microbial Metabolite Library | Mitochondria-Targeted Compound Library | Food-Sourced Compound Library | Anti-Cancer Natural Product Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Metabolic Enzyme Compound Library | Anti-Ovarian Cancer Compound Library | Radioprotector Library | Mitophagy Compound Library | Bioactive Compound Library Max | Rapamycin | Ferrostatin-1 | Cycloheximide | Doxorubicin hydrochloride | Bafilomycin A1 | Dimethyl sulfoxide | Dexamethasone | Acetylcysteine | H2DCFDA | Puromycin dihydrochloride | Staurosporine | Actinomycin D | Deferoxamine mesylate | MitoSOX Red | Etoposide | Elesclomol | G-418 disulfate | Nigericin sodium salt | 5-Azacytidine | Brefeldin A | CCCP | Estradiol | Quercetin | Ionomycin | Hygromycin B | Mitomycin C | L-Ascorbic acid | Resveratrol | Tunicamycin | Everolimus
品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物,我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物;10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域;设有专业的实验中心和严格的质控、验证体系;提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告,确保产品的高纯度、高品质;产品的生物活性多经各国客户实验验证;Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果;专业团队跟踪最新的制药及生命科学研究进展,为您提供全球最新的活性化合物;与世界各大制药公司及知名科研机构建立了长期的合作。