Hyperforin 产品活性：Hyperforin 是瞬时受体典型 6 (TRPC6) 通道激活剂。Hyperforin 通过激活 Ca2+ 传导非选择性典型 TRPC6 通道来调节 Ca2+ 水平。Hyperforin 还表现出多种药理活性，包括抗抑郁、抗肿瘤、抗痴呆、抗糖尿病等。Hyperforin 调节 γδ T 细胞分泌 IL-17α，改善 Imiquimod (HY-B0180) 诱导的银屑病样小鼠皮肤炎症。 产品来源： https://www.medchemexpress.cn/hyperforin.html 研究领域：Membrane Transporter/Ion Channel | Neuronal Signaling 作用靶点：Calcium Channel | TRP Channel 来源：植物 | 藤黄科 | 贯叶连翘 结构分类：抗生素 | 疾病研究 | 抗癌 | 抗生素 | 疾病研究 | 抗炎/免疫调剂 | 结构分类 In Vitro: Hyperforin has a multi-directional mechanism of action. It blocks conductance of ligand-gated (GABA, NMDA, and AMPA receptors) and voltage-gated channels (Ca2+, K+, and Na+). Hyperforin (0.1, 1, 10 μM; 2 h) reduces the expression and secretion of IL-17A in γδ T cell in vitro cultured murine splenic γδ T cells. Hyperforin (0.1, 1, 10 μM; 2 h) suppresses phosphorylation of MAPK and STAT3 pathways in TNF-α stimulated HaCaT cells. Hyperforin (IC50=3.7 μmol/L) inhibits the microvascular tube formation and proliferation of HDMEC in a dose-dependent manner without toxic effects. In Vivo: Hyperforin (5 mg/kg; i.p.; once daily for 7 d) ameliorates Imiquimod (HY-B0180)-induced psoriatic skin lesion in mice, as well as inhibiting inflammatory cell infiltration and inflammatory cytokines release. 相关产品：Thapsigargin | Rosiglitazone | Ionomycin | L-Ascorbic acid | GsMTx4 | Capsaicin | Minocycline hydrochloride | EIPA | Probenecid | Verapamil | 2-Aminoethyl diphenylborinate | Acetylcholine chloride | Diphenyleneiodonium chloride | Amiloride hydrochloride | GSK1016790A | Capsazepine | Nifedipine | Fasudil Hydrochloride | Ebselen | HC-067047 | Halofuginone | HC-030031 | ML-SA1 | Bay K 8644 | Carbamazepine | Tetrandrine 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。