耗材描述
Eckol
产品活性:Eckol是一种有效的 hMAO-A (混合性) 和 hMAO-B (非竞争性) 抑制剂,IC50 分别为 7.20 和 83.44 μM。Eckol 对玉米有刺激作用,可作为植物生物刺激素使用。Eckol 还显示抗过敏和抗病毒 (antiviral) 作用。
产品来源: https://www.medchemexpress.cn/eckol.html
研究领域:Neuronal Signaling | Anti-infection
作用靶点:Monoamine Oxidase | Influenza Virus
来源:植物 | 其他科 | Eisenia bicyclis
结构分类:酚类 | 多酚类 | 结构分类
In Vitro: Pretreatment with Eckol (25-100 μg/mL; 2 h) significantly reduces β-hexosaminidase release in IgE/BSA-stimulated BMCMC in a dose-dependent manner.
Eckol (25-100 μg/mL; 1 h) inhibits the production of Th2-type cytokines, such as IL-4, IL-5, and IL-13 as well as proinflammatory cytokines, such as IL-6.
Eckol (25-100 μg/mL) attenuates cytokine mRNA levels such as IL-1β, IL-4, IL-5, IL-6, IL-13, IFN-γ, and TNF-α in IgE/BSA-stimulated BMCMC.
Eckol (25-100 μg/mL; 1 h) inhibits NF-κB activation in IgE/BSA-stimulated BMCMC.
Eckol showes a moderate IC50 value (89.5 µM) against the influenza A/Bervig-Mission/1/18 (H1N1) virus.
In Vivo: Foliar application of Eckol (1 μM) significantly enhanced shoot and root length, shoot and root fresh and dry weight, leaf area and leaf number.
Eckol (50 or 100 μg/mouse; intradermal; once) reduces allergic inflammatory responses in the passive cutaneous anaphylaxis (PCA)-induced mice.
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