7α,25-Dihydroxycholesterol 产品活性：7α, 25-dihydroxycholesterol (7α,25-OHC) 是一种孤儿 GPCR 受体 EBI2 (GPR183) 的有效选择性激动剂和内源性配体。7α, 25-dihydroxycholesterol 对激活 EBI2 有很强的作用 (EC50=140 pM; Kd=450 pM)。7α, 25-dihydroxycholesterol 可作为一种趋化因子，指导 B 细胞、T 细胞和树突状细胞的迁移。 产品来源： https://www.medchemexpress.cn/7-alpha-25-dihydroxycholesterol.html 研究领域：GPCR/G Protein | Metabolic Enzyme/Protease 作用靶点：EBI2/GPR183 | Endogenous Metabolite 结构分类：甾体类 | 结构分类 In Vitro: 在体外，7α,25-Dihydroxycholesterol (7α,25-OHC) 刺激表达 EBI2 的小鼠 B 细胞和 T 细胞的迁移，半数最大有效浓度值约为 500 pM，但对 EBI2 缺陷细胞没有影响。 In Vivo: 7α,25-Dihydroxycholesterol (1 μM；1.5 小时) 预处理使 EBI2 缺陷型 B 细胞或正常 B 细胞脱敏，显示脾脏滤泡区域的归巢减少。 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | GPCR/G Protein Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | Natural Product Library | Antiviral Compound Library | Human Endogenous Metabolite Compound Library | Lipid Compound Library | Lipid Metabolism Compound Library | Food-Sourced Compound Library | Human Metabolite Library | Membrane Protein-targeted Compound Library | Membrane Receptor-targeted Compound Library | Animal-Sourced Natural Product Library | Highly Selective Activators Library | Bioactive Compound Library Max | Rapamycin | 3-Methyladenine | Acetylcysteine | 5-Fluorouracil | ATP | Retinoic acid | Hydrocortisone | Estradiol | Nicotinamide | Prostaglandin E2 | AICAR | Palmitic acid | Docetaxel | Isoprenaline hydrochloride | L-Ascorbic acid | Cytarabine | Melatonin | Calcitriol | Capsaicin | Arachidonic acid | Valproic acid | Oleic acid | β-Nicotinamide mononucleotide | Acetaminophen | Biotin | Corticosterone | Lactate | Cholesterol | NAD+ | DHEA 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。