耗材描述
Acetyl Coenzyme A trisodium
产品活性:Acetyl-coenzyme A (Acetyl-CoA) trisodium 是一种膜非渗透性的中枢代谢中间体,参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A trisodium 通过向目标氨基酸残基提供 (唯一供体) 乙酰基团,来完成蛋白质的翻译后乙酰化反应,从而调节各种细胞机制。Acetyl Coenzyme A trisodium 也是脂质合成的关键前体。
产品来源: https://www.medchemexpress.cn/acetyl-coenzyme-a-trisodium.html
研究领域:Metabolic Enzyme/Protease | Autophagy
作用靶点:Oxidative Phosphorylation | Endogenous Metabolite | Autophagy
结构分类:其他类 | 结构分类
In Vitro: Acetyl coenzyme A trisodium increases cytoplasmic protein acetylation in starved U2OS cells while reducing starvation-induced autophagic fluxes. (U2OS cells stably expressing GFP-LC3 and are microinjected with Acetyl coenzyme A trisodium; incubated in nutrient-free conditions in the presence of 100 nM BafA1 and fixed after 3 h).
In Vivo: Acetyl coenzyme A trisodium blunts pressure overload-induced cardiomyopathy in a mice cardiac pressure overload model by Suppressing maladaptive autophagy.?
Mice deprived of food (but with access to water ad libitum) for 24 h exhibit a significant reduction in total Acetyl coenzyme A trisodium levels in several organs, including the heart and muscles, corresponding to a decrease in protein acetylation levels. However, the same experimental conditions have no major effects on Acetyl coenzyme A trisodium concentrations in the brain and actually increase hepatic Acetyl coenzyme A trisodium and protein acetylation levels.
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