Protosappanin A 产品活性：Protosappanin A (PTA)，是一种免疫制剂，是从 Caesalpinia sappan L 中分离得到的一种主要联苯化合物，通过下调 JAK2 和 STAT3 的磷酸化，抑制 JAK2/STAT3 依赖的炎症通路。 产品来源： https://www.medchemexpress.cn/Protosappanin_A.html 研究领域：Epigenetics | Protein Tyrosine Kinase/RTK | JAK/STAT Signaling | Stem Cell/Wnt 作用靶点：JAK | STAT 来源：植物 | 豆科 | 苏木 结构分类：酚类 | 多酚类 | 结构分类 In Vitro: Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) significantly inhibits the production of TNF-α and IL-1β in LPS-activated BV2 microglia. And the mRNA expressions of IL-6, IL-1β, and MCP-1 are reduced by PTA in a dose-dependent manner in BV2 microglial cell line. Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) suppresses JAK2/STAT3-dependent inflammation pathway through down-regulating the phosphorylation of JAK2 and STAT3, as well as STAT3 nuclear translocation against LPS treatment. Protosappanin A (PTA: 12.5, 25, 50 μM, 24 hours) shows obvious effect on disturbing the interaction of transmembrane protein CD14 with Toll-like receptor-4, resulting in the inhibition of NF-κB-dependent oxidative and nitrative stress in LPS-induced BV2 microglia. 相关产品：Natural Product Library Plus | Bioactive Compound Library Plus | Epigenetics Compound Library | Immunology/Inflammation Compound Library | JAK/STAT Compound Library | Protein Tyrosine Kinase Compound Library | Stem Cell Signaling Compound Library | Natural Product Library | Small Molecule Immuno-Oncology Compound Library | Anti-Aging Compound Library | Phenols Library | Pyroptosis Compound Library | Traditional Chinese Medicine Active Compound Library | Anti-Lung Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Transcription Factor-Targeted Library | Anti-inflammatory Traditional Chinese Medicine Active Compound Library | Plant-Sourced Natural Product Library | Human Metabolite Library | Pain-Related Compound Library | Autoimmune Disease Compound Library | Multi-Target Compound Library | Bioactive Compound Library Max | Ruxolitinib | Stattic | Tofacitinib | Fludarabine | Deucravacitinib | Baricitinib | Upadacitinib | AG490 | Fedratinib | Cilengitide | Homoharringtonine | Niclosamide | AS1517499 | C188-9 | Artesunate | Ritlecitinib | TPCA-1 | Pacritinib | Colivelin TFA | Napabucasin | WP1066 | NSC 74859 | Momelotinib | STAT5-IN-1 | Butyzamide | Cryptotanshinone | Filgotinib | Astaxanthin 品牌介绍: MCE (MedChemExpress) 拥有数百种全球独家化合物，我们致力于为全球科研客户提供最新最全的高品质小分子活性化合物；10,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领域；设有专业的实验中心和严格的质控、验证体系；提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；产品的生物活性多经各国客户实验验证；Nature, Cell, Science 等多种顶级期刊及制药专利收录了MCE客户的科研成果；专业团队跟踪最新的制药及生命科学研究进展，为您提供全球最新的活性化合物；与世界各大制药公司及知名科研机构建立了长期的合作。